Frequency and Antimicrobial Susceptibility Profile of Acinetobacter baumannii Isolated at a Tertiary Care Diagnostic Facility
Objective: To evaluate the frequency and antimicrobial susceptibility pattern of Acinetobacter baumannii isolated at a tertiary care setting. Study Design: Cross sectional study. Place and Duration of Study: Department of Microbiology, Armed Forces Institute of Pathology, Rawalpindi Pakistan, f...
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| Format: | Article |
| Language: | English |
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Army Medical College Rawalpindi
2023-12-01
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| Series: | Pakistan Armed Forces Medical Journal |
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| Online Access: | https://www.pafmj.org/PAFMJ/article/view/10108 |
| _version_ | 1827370265484460032 |
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| author | Aamir Hussain Ihsan Ullah Khan Muhammad Qammar Saeed |
| author_facet | Aamir Hussain Ihsan Ullah Khan Muhammad Qammar Saeed |
| author_sort | Aamir Hussain |
| collection | DOAJ |
| description |
Objective: To evaluate the frequency and antimicrobial susceptibility pattern of Acinetobacter baumannii isolated at a tertiary care setting.
Study Design: Cross sectional study.
Place and Duration of Study: Department of Microbiology, Armed Forces Institute of Pathology, Rawalpindi Pakistan, from
July to Dec 2018.
Methodology: All the specimens submitted, which yielded the growth of Acinetobacter baumannii, were included in the study. Isolates were confirmed biochemically by using api 20NE. Antimicrobial susceptibility was done using standard procedures and as per CLSI's latest guidelines.
Results: Nine thousand nine hundred thirty-one specimens were submitted to the Microbiology Department AFIP for culture and antimicrobial susceptibility testing during the study period. Amongst these, 1633(16.5%) specimens yielded the growth of different pathogens. Of 1633 culture-positive isolates, 101(6.2%) were identified as Acinetobacter baumannii. Among these,34.6% of the isolates were recovered from respiratory specimens, while 29.7% from pus and pus swab specimens. Minocycline was the most sensitive antibiotic with 59.4% sensitivity, followed by Doxycycline, to which 48.5% of isolates were susceptible. Sensitivity to all other antimicrobials was 24% or less. In vitro, sensitivity to Carbapenems is very low.
Conclusion: Acinetobacter baumannii was isolated from 6.2% of specimens submitted for culture and susceptibility testing.
Minocycline was the most sensitive antibiotic, followed by Doxycycline. Sensitivity to most of the other antimicrobials was
24% or less. An alarming resistant pattern demands strict infection control practices and judicious use of antibiotics.
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| first_indexed | 2024-03-08T10:12:01Z |
| format | Article |
| id | doaj.art-b9616abd12ce427dadeac1456ac7d0a9 |
| institution | Directory Open Access Journal |
| issn | 0030-9648 2411-8842 |
| language | English |
| last_indexed | 2024-03-08T10:12:01Z |
| publishDate | 2023-12-01 |
| publisher | Army Medical College Rawalpindi |
| record_format | Article |
| series | Pakistan Armed Forces Medical Journal |
| spelling | doaj.art-b9616abd12ce427dadeac1456ac7d0a92024-01-29T08:22:25ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422023-12-0173610.51253/pafmj.v73i6.10108Frequency and Antimicrobial Susceptibility Profile of Acinetobacter baumannii Isolated at a Tertiary Care Diagnostic FacilityAamir Hussain0Ihsan Ullah Khan1Muhammad Qammar Saeed2Institute of Pathology and Diagnostic Medicine, Khyber Medical University, Peshawar PakistanInstitute of Pathology and Diagnostic Medicine, Khyber Medical University, Peshawar PakistanDepartment of Applied Biology, Bahauddin Zakriya University, Multan, Pakistan Objective: To evaluate the frequency and antimicrobial susceptibility pattern of Acinetobacter baumannii isolated at a tertiary care setting. Study Design: Cross sectional study. Place and Duration of Study: Department of Microbiology, Armed Forces Institute of Pathology, Rawalpindi Pakistan, from July to Dec 2018. Methodology: All the specimens submitted, which yielded the growth of Acinetobacter baumannii, were included in the study. Isolates were confirmed biochemically by using api 20NE. Antimicrobial susceptibility was done using standard procedures and as per CLSI's latest guidelines. Results: Nine thousand nine hundred thirty-one specimens were submitted to the Microbiology Department AFIP for culture and antimicrobial susceptibility testing during the study period. Amongst these, 1633(16.5%) specimens yielded the growth of different pathogens. Of 1633 culture-positive isolates, 101(6.2%) were identified as Acinetobacter baumannii. Among these,34.6% of the isolates were recovered from respiratory specimens, while 29.7% from pus and pus swab specimens. Minocycline was the most sensitive antibiotic with 59.4% sensitivity, followed by Doxycycline, to which 48.5% of isolates were susceptible. Sensitivity to all other antimicrobials was 24% or less. In vitro, sensitivity to Carbapenems is very low. Conclusion: Acinetobacter baumannii was isolated from 6.2% of specimens submitted for culture and susceptibility testing. Minocycline was the most sensitive antibiotic, followed by Doxycycline. Sensitivity to most of the other antimicrobials was 24% or less. An alarming resistant pattern demands strict infection control practices and judicious use of antibiotics. https://www.pafmj.org/PAFMJ/article/view/10108Acinetobacter bauamnniiAntimicrobial susceptibilityMulti-drug resistance |
| spellingShingle | Aamir Hussain Ihsan Ullah Khan Muhammad Qammar Saeed Frequency and Antimicrobial Susceptibility Profile of Acinetobacter baumannii Isolated at a Tertiary Care Diagnostic Facility Pakistan Armed Forces Medical Journal Acinetobacter bauamnnii Antimicrobial susceptibility Multi-drug resistance |
| title | Frequency and Antimicrobial Susceptibility Profile of Acinetobacter baumannii Isolated at a Tertiary Care Diagnostic Facility |
| title_full | Frequency and Antimicrobial Susceptibility Profile of Acinetobacter baumannii Isolated at a Tertiary Care Diagnostic Facility |
| title_fullStr | Frequency and Antimicrobial Susceptibility Profile of Acinetobacter baumannii Isolated at a Tertiary Care Diagnostic Facility |
| title_full_unstemmed | Frequency and Antimicrobial Susceptibility Profile of Acinetobacter baumannii Isolated at a Tertiary Care Diagnostic Facility |
| title_short | Frequency and Antimicrobial Susceptibility Profile of Acinetobacter baumannii Isolated at a Tertiary Care Diagnostic Facility |
| title_sort | frequency and antimicrobial susceptibility profile of acinetobacter baumannii isolated at a tertiary care diagnostic facility |
| topic | Acinetobacter bauamnnii Antimicrobial susceptibility Multi-drug resistance |
| url | https://www.pafmj.org/PAFMJ/article/view/10108 |
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