Design, Synthesis, and Antiprotozoal Evaluation of New Promising 2,9-<i>Bis</i>[(substituted-aminomethyl)]-4,7-phenyl-1,10-phenanthroline Derivatives, a Potential Alternative Scaffold to Drug Efflux

Design, Synthesis, and Antiprotozoal Evaluation of New Promising 2,9-<i>Bis</i>[(substituted-aminomethyl)]-4,7-phenyl-1,10-phenanthroline Derivatives, a Potential Alternative Scaffold to Drug Efflux

A series of novel 2,9-<i>bis</i>[(substituted-aminomethyl)]-4,7-phenyl-1,10-phenanthroline derivatives was designed, synthesized, and evaluated in vitro against three protozoan parasites (<i>Plasmodium falciparum</i>, <i>Leishmania donovani</i> and <i>Trypan...

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Main Authors: Jean Guillon, Anita Cohen, Clotilde Boudot, Sarah Monic, Solène Savrimoutou, Stéphane Moreau, Sandra Albenque-Rubio, Camille Lafon-Schmaltz, Alexandra Dassonville-Klimpt, Jean-Louis Mergny, Luisa Ronga, Mikel Bernabeu de Maria, Jeremy Lamarche, Cristina Dal Lago, Eric Largy, Valérie Gabelica, Serge Moukha, Pascale Dozolme, Patrice Agnamey, Nadine Azas, Catherine Mullié, Bertrand Courtioux, Pascal Sonnet
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Pathogens
Subjects:
antimalarial activity
phenanthroline
G-quadruplex
antileishmanial activity
antitrypanosomal activity
Online Access:https://www.mdpi.com/2076-0817/11/11/1339

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