Microglia and macrophage metabolism: a regulator of cerebral gliomas
Abstract Reciprocal interactions between the tumor microenvironment (TME) and cancer cells play important roles in tumorigenesis and progression of glioma. Glioma-associated macrophages (GAMs), either of peripheral origin or representing brain-intrinsic microglia, are the majority population of infi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | Cell & Bioscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13578-024-01231-7 |
| _version_ | 1827276924772155392 |
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| author | Yue Deng Qinyan Chen Chao Wan Yajie Sun Fang Huang Yan Hu Kunyu Yang |
| author_facet | Yue Deng Qinyan Chen Chao Wan Yajie Sun Fang Huang Yan Hu Kunyu Yang |
| author_sort | Yue Deng |
| collection | DOAJ |
| description | Abstract Reciprocal interactions between the tumor microenvironment (TME) and cancer cells play important roles in tumorigenesis and progression of glioma. Glioma-associated macrophages (GAMs), either of peripheral origin or representing brain-intrinsic microglia, are the majority population of infiltrating immune cells in glioma. GAMs, usually classified into M1 and M2 phenotypes, have remarkable plasticity and regulate tumor progression through different metabolic pathways. Recently, research efforts have increasingly focused on GAMs metabolism as potential targets for glioma therapy. This review aims to delineate the metabolic characteristics of GAMs within the TME and provide a summary of current therapeutic strategies targeting GAMs metabolism in glioma. The goal is to provide novel insights and therapeutic pathways for glioma by highlighting the significance of GAMs metabolism. |
| first_indexed | 2024-04-24T07:11:08Z |
| format | Article |
| id | doaj.art-b9624d52d641413eb525c853576a961e |
| institution | Directory Open Access Journal |
| issn | 2045-3701 |
| language | English |
| last_indexed | 2024-04-24T07:11:08Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell & Bioscience |
| spelling | doaj.art-b9624d52d641413eb525c853576a961e2024-04-21T11:31:34ZengBMCCell & Bioscience2045-37012024-04-0114111210.1186/s13578-024-01231-7Microglia and macrophage metabolism: a regulator of cerebral gliomasYue Deng0Qinyan Chen1Chao Wan2Yajie Sun3Fang Huang4Yan Hu5Kunyu Yang6Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Reciprocal interactions between the tumor microenvironment (TME) and cancer cells play important roles in tumorigenesis and progression of glioma. Glioma-associated macrophages (GAMs), either of peripheral origin or representing brain-intrinsic microglia, are the majority population of infiltrating immune cells in glioma. GAMs, usually classified into M1 and M2 phenotypes, have remarkable plasticity and regulate tumor progression through different metabolic pathways. Recently, research efforts have increasingly focused on GAMs metabolism as potential targets for glioma therapy. This review aims to delineate the metabolic characteristics of GAMs within the TME and provide a summary of current therapeutic strategies targeting GAMs metabolism in glioma. The goal is to provide novel insights and therapeutic pathways for glioma by highlighting the significance of GAMs metabolism.https://doi.org/10.1186/s13578-024-01231-7GliomaGlioma-associated macrophagesMetabolismTargeted therapy |
| spellingShingle | Yue Deng Qinyan Chen Chao Wan Yajie Sun Fang Huang Yan Hu Kunyu Yang Microglia and macrophage metabolism: a regulator of cerebral gliomas Cell & Bioscience Glioma Glioma-associated macrophages Metabolism Targeted therapy |
| title | Microglia and macrophage metabolism: a regulator of cerebral gliomas |
| title_full | Microglia and macrophage metabolism: a regulator of cerebral gliomas |
| title_fullStr | Microglia and macrophage metabolism: a regulator of cerebral gliomas |
| title_full_unstemmed | Microglia and macrophage metabolism: a regulator of cerebral gliomas |
| title_short | Microglia and macrophage metabolism: a regulator of cerebral gliomas |
| title_sort | microglia and macrophage metabolism a regulator of cerebral gliomas |
| topic | Glioma Glioma-associated macrophages Metabolism Targeted therapy |
| url | https://doi.org/10.1186/s13578-024-01231-7 |
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