Identification of Small Molecule Inhibitors against <i>Staphylococcus aureus</i> Dihydroorotase via HTS

Identification of Small Molecule Inhibitors against <i>Staphylococcus aureus</i> Dihydroorotase via HTS

Drug-resistant <i>Staphylococcus aureus</i> is an imminent threat to public health, increasing the importance of drug discovery utilizing unexplored bacterial pathways and enzyme targets. <i>De novo</i> pyrimidine biosynthesis is a specialized, highly conserved pathway implic...

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Bibliographic Details
Main Authors: Amy J. Rice, Russell P. Pesavento, Jinhong Ren, Isoo Youn, Youngjin Kwon, Kassapa Ellepola, Chun-Tao Che, Michael E. Johnson, Hyun Lee
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
<i>S. aureus</i>
antimicrobial
dihydroorotase
Class I DHOase
inhibitors
Online Access:https://www.mdpi.com/1422-0067/22/18/9984

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