Antiviral Treatment of Maternal and Congenital Cytomegalovirus (CMV) Infections
Human Cytomegalovirus (HCMV) is a ubiquitous member of the Herpesviridae family, responsible for the most common congenital viral infection—congenital Cytomegalovirus (cCMV) infection. While a majority of HCMV infections in children and adults are asymptomatic, HCMV is well known to cause severe inf...
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| Format: | Article |
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MDPI AG
2023-10-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/10/2116 |
| _version_ | 1797572047560245248 |
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| author | Swetha Pinninti Suresh Boppana |
| author_facet | Swetha Pinninti Suresh Boppana |
| author_sort | Swetha Pinninti |
| collection | DOAJ |
| description | Human Cytomegalovirus (HCMV) is a ubiquitous member of the Herpesviridae family, responsible for the most common congenital viral infection—congenital Cytomegalovirus (cCMV) infection. While a majority of HCMV infections in children and adults are asymptomatic, HCMV is well known to cause severe infections in the immunocompromised individual and maternal infections with variable long-term sequelae after maternal–fetal transmission with primary or nonprimary infections. HCMV seroprevalence and cCMV incidence vary by geographic area and demographic characteristics like race and socioeconomic status. While cCMV birth prevalence ranges from 0.2% to 6% in different parts of the world, it is influenced by regional HCMV seroprevalence rates. HCMV screening during pregnancy is not routinely offered due to lack of awareness, hurdles to accurate diagnosis, and lack of well-established effective treatment options during pregnancy. This review will focus on antiviral treatment options currently available for use during pregnancy and in the newborn period for the treatment of maternal and congenital HCMV infections. |
| first_indexed | 2024-03-10T20:50:10Z |
| format | Article |
| id | doaj.art-b9636279c4ee4ae5a94441f41c832e1b |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T20:50:10Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-b9636279c4ee4ae5a94441f41c832e1b2023-11-19T18:28:33ZengMDPI AGViruses1999-49152023-10-011510211610.3390/v15102116Antiviral Treatment of Maternal and Congenital Cytomegalovirus (CMV) InfectionsSwetha Pinninti0Suresh Boppana1Department of Pediatrics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USADepartment of Pediatrics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USAHuman Cytomegalovirus (HCMV) is a ubiquitous member of the Herpesviridae family, responsible for the most common congenital viral infection—congenital Cytomegalovirus (cCMV) infection. While a majority of HCMV infections in children and adults are asymptomatic, HCMV is well known to cause severe infections in the immunocompromised individual and maternal infections with variable long-term sequelae after maternal–fetal transmission with primary or nonprimary infections. HCMV seroprevalence and cCMV incidence vary by geographic area and demographic characteristics like race and socioeconomic status. While cCMV birth prevalence ranges from 0.2% to 6% in different parts of the world, it is influenced by regional HCMV seroprevalence rates. HCMV screening during pregnancy is not routinely offered due to lack of awareness, hurdles to accurate diagnosis, and lack of well-established effective treatment options during pregnancy. This review will focus on antiviral treatment options currently available for use during pregnancy and in the newborn period for the treatment of maternal and congenital HCMV infections.https://www.mdpi.com/1999-4915/15/10/2116cytomegaloviruscongenitalganciclovirvalacyclovirmaternal–fetal infections |
| spellingShingle | Swetha Pinninti Suresh Boppana Antiviral Treatment of Maternal and Congenital Cytomegalovirus (CMV) Infections Viruses cytomegalovirus congenital ganciclovir valacyclovir maternal–fetal infections |
| title | Antiviral Treatment of Maternal and Congenital Cytomegalovirus (CMV) Infections |
| title_full | Antiviral Treatment of Maternal and Congenital Cytomegalovirus (CMV) Infections |
| title_fullStr | Antiviral Treatment of Maternal and Congenital Cytomegalovirus (CMV) Infections |
| title_full_unstemmed | Antiviral Treatment of Maternal and Congenital Cytomegalovirus (CMV) Infections |
| title_short | Antiviral Treatment of Maternal and Congenital Cytomegalovirus (CMV) Infections |
| title_sort | antiviral treatment of maternal and congenital cytomegalovirus cmv infections |
| topic | cytomegalovirus congenital ganciclovir valacyclovir maternal–fetal infections |
| url | https://www.mdpi.com/1999-4915/15/10/2116 |
| work_keys_str_mv | AT swethapinninti antiviraltreatmentofmaternalandcongenitalcytomegaloviruscmvinfections AT sureshboppana antiviraltreatmentofmaternalandcongenitalcytomegaloviruscmvinfections |