A simplified function-first method for the discovery and optimization of bispecific immune engaging antibodies

A simplified function-first method for the discovery and optimization of bispecific immune engaging antibodies

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Bi-specific T-cell engager antibodies (BiTEs) are synthetic fusion molecules that combine multiple antibody-binding domains to induce active contact between T-cells and antigen expressing cells in the body. Blinatumomab, a CD19-CD3 BiTE is now a widely used therapy for relapsed B-cell malignancies,...

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Bibliographic Details
Main Authors: Alex Shepherd, Bigitha Bennychen, Anne Marcil, Darin Bloemberg, Robert A. Pon, Risini D. Weeratna, Scott McComb
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10286961/?tool=EBI

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