Mechanisms, Effects, and Management of Neurological Complications of Post-Acute Sequelae of COVID-19 (NC-PASC)
With a growing number of patients entering the recovery phase following infection with SARS-CoV-2, understanding the long-term neurological consequences of the disease is important to their care. The neurological complications of post-acute sequelae of SARS-CoV-2 infection (NC-PASC) represent a myri...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/11/2/377 |
| _version_ | 1797622237671456768 |
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| author | Ian Z. Ong Dennis L. Kolson Matthew K. Schindler |
| author_facet | Ian Z. Ong Dennis L. Kolson Matthew K. Schindler |
| author_sort | Ian Z. Ong |
| collection | DOAJ |
| description | With a growing number of patients entering the recovery phase following infection with SARS-CoV-2, understanding the long-term neurological consequences of the disease is important to their care. The neurological complications of post-acute sequelae of SARS-CoV-2 infection (NC-PASC) represent a myriad of symptoms including headaches, brain fog, numbness/tingling, and other neurological symptoms that many people report long after their acute infection has resolved. Emerging reports are being published concerning COVID-19 and its chronic effects, yet limited knowledge of disease mechanisms has challenged therapeutic efforts. To address these issues, we review broadly the literature spanning 2020–2022 concerning the proposed mechanisms underlying NC-PASC, outline the long-term neurological sequelae associated with COVID-19, and discuss potential clinical interventions. |
| first_indexed | 2024-03-11T09:07:15Z |
| format | Article |
| id | doaj.art-b964969b097f4c5f946099e142a7380c |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T09:07:15Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-b964969b097f4c5f946099e142a7380c2023-11-16T19:17:20ZengMDPI AGBiomedicines2227-90592023-01-0111237710.3390/biomedicines11020377Mechanisms, Effects, and Management of Neurological Complications of Post-Acute Sequelae of COVID-19 (NC-PASC)Ian Z. Ong0Dennis L. Kolson1Matthew K. Schindler2Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USADepartment of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USADepartment of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USAWith a growing number of patients entering the recovery phase following infection with SARS-CoV-2, understanding the long-term neurological consequences of the disease is important to their care. The neurological complications of post-acute sequelae of SARS-CoV-2 infection (NC-PASC) represent a myriad of symptoms including headaches, brain fog, numbness/tingling, and other neurological symptoms that many people report long after their acute infection has resolved. Emerging reports are being published concerning COVID-19 and its chronic effects, yet limited knowledge of disease mechanisms has challenged therapeutic efforts. To address these issues, we review broadly the literature spanning 2020–2022 concerning the proposed mechanisms underlying NC-PASC, outline the long-term neurological sequelae associated with COVID-19, and discuss potential clinical interventions.https://www.mdpi.com/2227-9059/11/2/377COVID-19SARS-CoV-2PASClong COVIDneurology |
| spellingShingle | Ian Z. Ong Dennis L. Kolson Matthew K. Schindler Mechanisms, Effects, and Management of Neurological Complications of Post-Acute Sequelae of COVID-19 (NC-PASC) Biomedicines COVID-19 SARS-CoV-2 PASC long COVID neurology |
| title | Mechanisms, Effects, and Management of Neurological Complications of Post-Acute Sequelae of COVID-19 (NC-PASC) |
| title_full | Mechanisms, Effects, and Management of Neurological Complications of Post-Acute Sequelae of COVID-19 (NC-PASC) |
| title_fullStr | Mechanisms, Effects, and Management of Neurological Complications of Post-Acute Sequelae of COVID-19 (NC-PASC) |
| title_full_unstemmed | Mechanisms, Effects, and Management of Neurological Complications of Post-Acute Sequelae of COVID-19 (NC-PASC) |
| title_short | Mechanisms, Effects, and Management of Neurological Complications of Post-Acute Sequelae of COVID-19 (NC-PASC) |
| title_sort | mechanisms effects and management of neurological complications of post acute sequelae of covid 19 nc pasc |
| topic | COVID-19 SARS-CoV-2 PASC long COVID neurology |
| url | https://www.mdpi.com/2227-9059/11/2/377 |
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