Insomnia and circadian misalignment: an underexplored interaction towards cardiometabolic risk
Insomnia remains the most prevalent sleep disorder worldwide, and its pathophysiology suggests an interface with circadian rhythm sleep-wake disorders (CRSWDs). Some epidemiological studies have linked insomnia and circadian misalignment with adverse cardiometabolic outcomes,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Thieme Revinter Publicações Ltda.
2021-03-01
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| Series: | Sleep Science |
| Subjects: | |
| Online Access: | https://sleepscience.org.br/export-pdf/2911/v14n1a09.pdf |
| Summary: | Insomnia remains the most prevalent sleep disorder worldwide, and its pathophysiology suggests
an interface with circadian rhythm sleep-wake disorders (CRSWDs). Some epidemiological studies
have linked insomnia and circadian misalignment with adverse cardiometabolic outcomes, but the
mechanisms underlying this relationship are still unclear. The autonomic nervous system (ANS) has
been pointed out as a crucial/key mediator that triggers cardiometabolic risk. Therefore, a critical
review of the literature focused on the past ten years was conducted to highlight the relationship
between insomnia, circadian misalignment and cardiometabolic risk, with particular emphasis
on the influence of the ANS. Shift work, as a model of circadian misalignment, was shown to
increase both cardiovascular and metabolic risk and so may integrate a proof of concept on this
link. Furthermore, there is good evidence from previous studies supporting that cardiac autonomic
dysfunction is indeed a possible mechanism that potentiates cardiometabolic risk in insomniacs
and individuals with a misalignment of the circadian timing system (e.g., shift workers), via changes
in autonomic variables. Further research is however required in order to definitively establish this
interactive relationship. |
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| ISSN: | 1984-0659 1984-0063 |