A novel adeno-associated viral variant for efficient and selective intravitreal transduction of rat Müller cells.

A novel adeno-associated viral variant for efficient and selective intravitreal transduction of rat Müller cells.

BACKGROUND:The pathologies of numerous retinal degenerative diseases can be attributed to a multitude of genetic factors, and individualized treatment options for afflicted patients are limited and cost-inefficient. In light of the shared neurodegenerative phenotype among these disorders, a safe and...

Full description

Bibliographic Details
Main Authors:	Ryan R Klimczak, James T Koerber, Deniz Dalkara, John G Flannery, David V Schaffer
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2009-10-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC2758586?pdf=render

Similar Items

Characterization of Recombinant Adeno-Associated Viral Transduction and Safety Profiles in Cardiomyocytes
by: Jianzhong Ai, et al.
Published: (2018-08-01)

Intravitreal injection of new adeno-associated viral vector: Enhancing retinoschisin 1 gene transduction in a mouse model of X-linked retinoschisis
by: Yan Sun, et al.
Published: (2024-03-01)

Recombinant adeno-associated virus: efficient transduction of the rat VMH and clearance from blood.
by: Margriet A van Gestel, et al.
Published: (2014-01-01)

Transduction of rat pancreatic islets with pseudotyped adeno-associated virus vectors
by: Blanchette-Mackie E Joan, et al.
Published: (2009-05-01)

Biophysical characterization of adeno-associated virus capsid through the viral transduction life cycle
by: Yanqiao Shawn Xiang, et al.
Published: (2023-05-01)

Hyperthermia Enhances Adeno-Associated Virus Vector Transduction Efficiency in Melanoma Cells
by: Alicja Bieńkowska-Tokarczyk, et al.
Published: (2023-10-01)

Capsid Mutated Adeno-Associated Virus Delivered to the Anterior Chamber Results in Efficient Transduction of Trabecular Meshwork in Mouse and Rat.
by: Barbara Bogner, et al.
Published: (2015-01-01)

Adeno-Associated Viral Vector 2 and 9 Transduction Is Enhanced in Streptozotocin-Induced Diabetic Mouse Retina
by: Si Hyung Lee, et al.
Published: (2019-06-01)

Transduction Patterns of Adeno-associated Viral Vectors in a Laser-Induced Choroidal Neovascularization Mouse Model
by: Si Hyung Lee, et al.
Published: (2018-06-01)

The tyrosine capsid mutations on retrograde adeno-associated virus accelerates gene transduction efficiency
by: Ryota Nakahama, et al.
Published: (2022-08-01)

The SUMOylation Pathway Restricts Gene Transduction by Adeno-Associated Viruses.
by: Christina Hölscher, et al.
Published: (2015-12-01)

Self-Complementary Adeno-Associated Virus Vectors Improve Transduction Efficiency of Corneal Endothelial Cells.
by: Anja K Gruenert, et al.
Published: (2016-01-01)

Pre-retinal delivery of recombinant adeno-associated virus vector significantly improves retinal transduction efficiency
by: Hanmeng Zhang, et al.
Published: (2021-09-01)

Dyslipidemia modulates Müller glial sensing and transduction of ambient information
by: Monika Lakk, et al.
Published: (2018-01-01)

Efficient delivery of Cre-recombinase to neurons in vivo and stable transduction of neurons using adeno-associated and lentiviral vectors
by: Sablitzky Fred, et al.
Published: (2004-01-01)

Efficient Early and Sustained Transduction of Human Fetal Mesencephalon Using Adeno-Associated Virus Type 2 Vectors
by: L. Tenenbaum, et al.
Published: (2004-07-01)

Specific tools for targeting and expression in Müller glial cells
by: Lucie P Pellissier, et al.
Published: (2014-01-01)

An adeno-associated viral vector transduces the rat hypothalamus and amygdala more efficient than a lentiviral vector
by: Vreugdenhil Erno, et al.
Published: (2010-07-01)

Efficient engraftment and viral transduction of human hepatocytes in an FRG rat liver humanization model
by: Marisa Carbonaro, et al.
Published: (2022-08-01)

Impact of Medium-Sized Extracellular Vesicles on the Transduction Efficiency of Adeno-Associated Viruses in Neuronal and Primary Astrocyte Cell Cultures
by: Orsolya Tünde Kovács, et al.
Published: (2021-04-01)

Co-transduction of dual-adeno-associated virus vectors in the neonatal and adult mouse utricles
by: Zhong-Rui Chen, et al.
Published: (2022-10-01)

Transduction characteristics of alternative adeno-associated virus serotypes in the cat brain by intracisternal delivery
by: Jacqueline E. Hunter, et al.
Published: (2022-09-01)

Adeno-associated viral vectors do not efficiently target muscle satellite cells
by: Andrea LH Arnett, et al.
Published: (2014-01-01)

Adeno-Associated Virus (AAV) - Based Gene Therapies for Retinal Diseases: Where are We?
by: Ail D, et al.
Published: (2023-05-01)

Adeno-Associated Viral Vectors in Neuroscience Research
by: David L. Haggerty, et al.
Published: (2020-06-01)

In situ transduction of cells in human corneal limbus using adeno-associated viruses: an ex vivo study
by: Hyeck-Soo Son, et al.
Published: (2022-12-01)

Peripapillary Intravitreal Injection Improves AAV-Mediated Retinal Transduction
by: Sanjar Batirovich Madrakhimov, et al.
Published: (2020-06-01)

Host Cell Restriction Factors Blocking Efficient Vector Transduction: Challenges in Lentiviral and Adeno-Associated Vector Based Gene Therapies
by: Ana Sofia Coroadinha
Published: (2023-02-01)

Self-complementarity in adeno-associated virus enhances transduction and gene expression in mouse cochlear tissues.
by: Graham Casey, et al.
Published: (2020-01-01)

Adeno-associated virus vector intraperitoneal injection induces colonic mucosa and submucosa transduction and alters the diversity and composition of the faecal microbiota in rats
by: Li-Tian Ma, et al.
Published: (2022-12-01)

Linking YAP to Müller Glia Quiescence Exit in the Degenerative Retina
by: Annaïg Hamon, et al.
Published: (2019-05-01)

Correction: Adeno-Associated Viral Vector Serotype 5 Poorly Transduces Liver in Rat Models
Published: (2014-01-01)

Correction: Adeno-Associated Viral Vector Serotype 5 Poorly Transduces Liver in Rat Models.
Published: (2014-01-01)

Correction: Adeno-associated viral vector serotype 5 poorly transduces liver in rat models.
by: PLOS ONE Staff
Published: (2015-01-01)

Lack of repeat transduction by recombinant adeno-associated virus type 5/5 vectors in the mouse airway.
by: Sumner-Jones, S, et al.
Published: (2007)

Extracellular vesicles enhance pulmonary transduction of stably associated adeno‐associated virus following intratracheal administration
by: Gijung Kwak, et al.
Published: (2023-06-01)

Transduction of Adeno-Associated Virus Vectors Targeting Hair Cells and Supporting Cells in the Neonatal Mouse Cochlea
by: Xi Gu, et al.
Published: (2019-01-01)

Cell-penetrating peptides enhance the transduction of adeno-associated virus serotype 9 in the central nervous system
by: Yuan Meng, et al.
Published: (2022-09-01)

Cell-penetrating peptides enhance the transduction of adeno-associated virus serotype 9 in the central nervous system
by: Yuan Meng, et al.
Published: (2021-06-01)

Immune Responses to Gene Editing by Viral and Non-Viral Delivery Vectors Used in Retinal Gene Therapy
by: Duohao Ren, et al.
Published: (2022-09-01)