Functional fission of parvalbumin interneuron classes during fast network events
Fast spiking, parvalbumin (PV) expressing hippocampal interneurons are classified into basket, axo-axonic (chandelier), and bistratified cells. These cell classes play key roles in regulating local circuit operations and rhythmogenesis by releasing GABA in precise temporal patterns onto distinct dom...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2014-11-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/04006 |
| _version_ | 1811253325429997568 |
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| author | Csaba Varga Mikko Oijala Jonathan Lish Gergely G Szabo Marianne Bezaire Ivan Marchionni Peyman Golshani Ivan Soltesz |
| author_facet | Csaba Varga Mikko Oijala Jonathan Lish Gergely G Szabo Marianne Bezaire Ivan Marchionni Peyman Golshani Ivan Soltesz |
| author_sort | Csaba Varga |
| collection | DOAJ |
| description | Fast spiking, parvalbumin (PV) expressing hippocampal interneurons are classified into basket, axo-axonic (chandelier), and bistratified cells. These cell classes play key roles in regulating local circuit operations and rhythmogenesis by releasing GABA in precise temporal patterns onto distinct domains of principal cells. In this study, we show that each of the three major PV cell classes further splits into functionally distinct sub-classes during fast network events in vivo. During the slower (<10 Hz) theta oscillations, each cell class exhibited its own characteristic, relatively uniform firing behavior. However, during faster (>90 Hz) oscillations, within-class differences in PV interneuron discharges emerged, which segregated along specific features of dendritic structure or somatic location. Functional divergence of PV sub-classes during fast but not slow network oscillations effectively doubles the repertoire of spatio-temporal patterns of GABA release available for rapid circuit operations. |
| first_indexed | 2024-04-12T16:49:09Z |
| format | Article |
| id | doaj.art-b9677be112574a84831cb85e149b4f0e |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T16:49:09Z |
| publishDate | 2014-11-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-b9677be112574a84831cb85e149b4f0e2022-12-22T03:24:28ZengeLife Sciences Publications LtdeLife2050-084X2014-11-01310.7554/eLife.04006Functional fission of parvalbumin interneuron classes during fast network eventsCsaba Varga0Mikko Oijala1Jonathan Lish2Gergely G Szabo3Marianne Bezaire4Ivan Marchionni5Peyman Golshani6Ivan Soltesz7Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, United States; Szentágothai Research Center, MTA-PTE-NAP A-Entorhinal Microcircuits, Department of Physiology, University of Pécs, Pécs, HungaryDepartment of Anatomy and Neurobiology, University of California, Irvine, Irvine, United StatesDepartment of Anatomy and Neurobiology, University of California, Irvine, Irvine, United StatesDepartment of Anatomy and Neurobiology, University of California, Irvine, Irvine, United StatesDepartment of Anatomy and Neurobiology, University of California, Irvine, Irvine, United StatesDepartment of Anatomy and Neurobiology, University of California, Irvine, Irvine, United StatesDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States; West Los Angeles, VA Medical Center, Los Angeles, United StatesDepartment of Anatomy and Neurobiology, University of California, Irvine, Irvine, United StatesFast spiking, parvalbumin (PV) expressing hippocampal interneurons are classified into basket, axo-axonic (chandelier), and bistratified cells. These cell classes play key roles in regulating local circuit operations and rhythmogenesis by releasing GABA in precise temporal patterns onto distinct domains of principal cells. In this study, we show that each of the three major PV cell classes further splits into functionally distinct sub-classes during fast network events in vivo. During the slower (<10 Hz) theta oscillations, each cell class exhibited its own characteristic, relatively uniform firing behavior. However, during faster (>90 Hz) oscillations, within-class differences in PV interneuron discharges emerged, which segregated along specific features of dendritic structure or somatic location. Functional divergence of PV sub-classes during fast but not slow network oscillations effectively doubles the repertoire of spatio-temporal patterns of GABA release available for rapid circuit operations.https://elifesciences.org/articles/04006oscillationinhibitionin vivo |
| spellingShingle | Csaba Varga Mikko Oijala Jonathan Lish Gergely G Szabo Marianne Bezaire Ivan Marchionni Peyman Golshani Ivan Soltesz Functional fission of parvalbumin interneuron classes during fast network events eLife oscillation inhibition in vivo |
| title | Functional fission of parvalbumin interneuron classes during fast network events |
| title_full | Functional fission of parvalbumin interneuron classes during fast network events |
| title_fullStr | Functional fission of parvalbumin interneuron classes during fast network events |
| title_full_unstemmed | Functional fission of parvalbumin interneuron classes during fast network events |
| title_short | Functional fission of parvalbumin interneuron classes during fast network events |
| title_sort | functional fission of parvalbumin interneuron classes during fast network events |
| topic | oscillation inhibition in vivo |
| url | https://elifesciences.org/articles/04006 |
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