Integrated genomic, transcriptomic and metabolomic analysis reveals MDH2 mutation-induced metabolic disorder in recurrent focal segmental glomerulosclerosis

Integrated genomic, transcriptomic and metabolomic analysis reveals MDH2 mutation-induced metabolic disorder in recurrent focal segmental glomerulosclerosis

Focal segmental glomerulosclerosis (FSGS) has an over 30% risk of recurrence after kidney transplantation (Ktx) and is associated with an extremely high risk of graft loss. However, mechanisms remain largely unclear. Thus, this study identifies novel genes related to the recurrence of FSGS (rFSGS)....

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Bibliographic Details
Main Authors: Qixia Shen, Lisha Teng, Yucheng Wang, Luying Guo, Feng Xu, Hongfeng Huang, Wenqing Xie, Qin Zhou, Ying Chen, Junwen Wang, Youying Mao, Jianghua Chen, Hong Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
recurrent focal segmental glomerulosclerosis
kidney transplantation
whole genome sequencing
next-generation RNA sequencing
MDH2
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.962986/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.962986/full

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