Chemoinformatic design and profiling of some derivatives of 1, 2, 4-oxadiazole as potential dengue virus NS-5 inhibitors

Chemoinformatic design and profiling of some derivatives of 1, 2, 4-oxadiazole as potential dengue virus NS-5 inhibitors

Abstract Background Dengue virus (DENV) infection is spreading rapidly, especially in the subtropical and tropical regions, placing a huge percentage of the global population at risk and causing repeated outbreaks. DENV protease inhibition has been suggested as a viable therapeutic strategy. Using a...

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Bibliographic Details
Main Authors: Samuel Ndaghiya Adawara, Gideon Adamu Shallangwa, Paul Andrew Mamza, Ibrahim Abdulkadir
Format: Article
Language:English
Published: SpringerOpen 2022-03-01
Series:Bulletin of the National Research Centre
Subjects:
Pharmacophore
Molecular docking
1, 2, 4-Oxadiazole
Computer-aided drug design
Drug-likeness
Online Access:https://doi.org/10.1186/s42269-022-00755-7

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