The Natural Product Parthenolide Inhibits Both Angiogenesis and Invasiveness and Improves Gemcitabine Resistance by Suppressing Nuclear Factor κB Activation in Pancreatic Cancer Cell Lines

The Natural Product Parthenolide Inhibits Both Angiogenesis and Invasiveness and Improves Gemcitabine Resistance by Suppressing Nuclear Factor κB Activation in Pancreatic Cancer Cell Lines

We previously established pancreatic cancer (PaCa) cell lines resistant to gemcitabine and found that the activity of nuclear factor κB (NF-κB) was enhanced upon the acquisition of gemcitabine resistance. Parthenolide, the main active ingredient in feverfew, has been reported to exhibit antitumor ac...

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Bibliographic Details
Main Authors: Yuki Denda, Yoichi Matsuo, Saburo Sugita, Yuki Eguchi, Keisuke Nonoyama, Hiromichi Murase, Tomokatsu Kato, Hiroyuki Imafuji, Kenta Saito, Mamoru Morimoto, Ryo Ogawa, Hiroki Takahashi, Akira Mitsui, Masahiro Kimura, Shuji Takiguchi
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Nutrients
Subjects:
parthenolide
pancreatic cancer
gemcitabine resistance
NF-κB
invasion
angiogenesis
Online Access:https://www.mdpi.com/2072-6643/16/5/705

Internet

https://www.mdpi.com/2072-6643/16/5/705

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