Prognostic analysis of peripheral blood inflammatory markers in 99 nasopharyngeal carcinoma patients with recurrence and metastasis
Abstract Objective Nasopharyngeal carcinoma (NPC) is a common malignant tumor in China; furthermore, >80% of cases worldwide occur in South China. This study analyzed the use of peripheral blood inflammatory markers as prognostic factors in patients with local recurrence and distant metastasis af...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-03-01
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| Series: | Precision Radiation Oncology |
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| Online Access: | https://doi.org/10.1002/pro6.1084 |
| _version_ | 1818573128938291200 |
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| author | Weiguo Gu Feng Yu Qiao Mao Feng Qiu |
| author_facet | Weiguo Gu Feng Yu Qiao Mao Feng Qiu |
| author_sort | Weiguo Gu |
| collection | DOAJ |
| description | Abstract Objective Nasopharyngeal carcinoma (NPC) is a common malignant tumor in China; furthermore, >80% of cases worldwide occur in South China. This study analyzed the use of peripheral blood inflammatory markers as prognostic factors in patients with local recurrence and distant metastasis after radiochemotherapy for NPC. Methods A retrospective analysis was carried out on the prognosis of 99 NPC patients with pathological and imaging diagnosis after radiochemotherapy at The First Affiliated Hospital of Nanchang University between 2010 and 2018．The Kaplan–Meier method was used to calculate survival rates, log–rank tests were used for univariate prognostic analysis, and a Cox regression model was used for multivariate prognostic analysis. Results Univariate analysis showed that treatment plan (χ2 = 8.895, P = 0.003), primary platelet count (χ2 = 3.92, P = 0.048), and primary lactate dehydrogenase level (LDH; χ2 = 22.138, P < 0.001) were positively correlated with survival time. Multivariable analysis showed that treatment plan (hazard ratio 2.103, 95% confidence interval 1.276 to –3.469, P = 0.004) and LDH (hazard ratio 2.711, 95% confidence interval 1.714–4.289, P < 0.001) were independent risk factors for NPC. Conclusions Treatment plan, primary platelet count, and primary LDH were positively correlated with survival time. Treatment plan and primary LDH level were independent risk factors for patients with recurrent or metastatic nasopharyngeal carcinoma. |
| first_indexed | 2024-12-15T00:06:57Z |
| format | Article |
| id | doaj.art-b969e22d08db45d385d0dde045d4a0a1 |
| institution | Directory Open Access Journal |
| issn | 2398-7324 |
| language | English |
| last_indexed | 2024-12-15T00:06:57Z |
| publishDate | 2020-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Precision Radiation Oncology |
| spelling | doaj.art-b969e22d08db45d385d0dde045d4a0a12022-12-21T22:42:43ZengWileyPrecision Radiation Oncology2398-73242020-03-0141182410.1002/pro6.1084Prognostic analysis of peripheral blood inflammatory markers in 99 nasopharyngeal carcinoma patients with recurrence and metastasisWeiguo Gu0Feng Yu1Qiao Mao2Feng Qiu3First Affiliated Hospital of Nanchang University Nanchang ChinaFirst Affiliated Hospital of Nanchang University Nanchang ChinaShangrao Maternity and Child Health Hospital Shangrao ChinaFirst Affiliated Hospital of Nanchang University Nanchang ChinaAbstract Objective Nasopharyngeal carcinoma (NPC) is a common malignant tumor in China; furthermore, >80% of cases worldwide occur in South China. This study analyzed the use of peripheral blood inflammatory markers as prognostic factors in patients with local recurrence and distant metastasis after radiochemotherapy for NPC. Methods A retrospective analysis was carried out on the prognosis of 99 NPC patients with pathological and imaging diagnosis after radiochemotherapy at The First Affiliated Hospital of Nanchang University between 2010 and 2018．The Kaplan–Meier method was used to calculate survival rates, log–rank tests were used for univariate prognostic analysis, and a Cox regression model was used for multivariate prognostic analysis. Results Univariate analysis showed that treatment plan (χ2 = 8.895, P = 0.003), primary platelet count (χ2 = 3.92, P = 0.048), and primary lactate dehydrogenase level (LDH; χ2 = 22.138, P < 0.001) were positively correlated with survival time. Multivariable analysis showed that treatment plan (hazard ratio 2.103, 95% confidence interval 1.276 to –3.469, P = 0.004) and LDH (hazard ratio 2.711, 95% confidence interval 1.714–4.289, P < 0.001) were independent risk factors for NPC. Conclusions Treatment plan, primary platelet count, and primary LDH were positively correlated with survival time. Treatment plan and primary LDH level were independent risk factors for patients with recurrent or metastatic nasopharyngeal carcinoma.https://doi.org/10.1002/pro6.1084metastaticnasopharyngeal carcinomaprognosisrecurrent |
| spellingShingle | Weiguo Gu Feng Yu Qiao Mao Feng Qiu Prognostic analysis of peripheral blood inflammatory markers in 99 nasopharyngeal carcinoma patients with recurrence and metastasis Precision Radiation Oncology metastatic nasopharyngeal carcinoma prognosis recurrent |
| title | Prognostic analysis of peripheral blood inflammatory markers in 99 nasopharyngeal carcinoma patients with recurrence and metastasis |
| title_full | Prognostic analysis of peripheral blood inflammatory markers in 99 nasopharyngeal carcinoma patients with recurrence and metastasis |
| title_fullStr | Prognostic analysis of peripheral blood inflammatory markers in 99 nasopharyngeal carcinoma patients with recurrence and metastasis |
| title_full_unstemmed | Prognostic analysis of peripheral blood inflammatory markers in 99 nasopharyngeal carcinoma patients with recurrence and metastasis |
| title_short | Prognostic analysis of peripheral blood inflammatory markers in 99 nasopharyngeal carcinoma patients with recurrence and metastasis |
| title_sort | prognostic analysis of peripheral blood inflammatory markers in 99 nasopharyngeal carcinoma patients with recurrence and metastasis |
| topic | metastatic nasopharyngeal carcinoma prognosis recurrent |
| url | https://doi.org/10.1002/pro6.1084 |
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