Lipid-Lowering Polyketides from the Fungus Penicillium Steckii HDN13-279
Seven new polyketides, named tanzawaic acids R–X (1–6, 11), along with seven known analogues (7–10 and 12–14), were isolated from Penicillium steckii HDN13-279. Their structures, including the absolute configurations, were elucidated by NMR, MS, X-ray diffraction, circular dichroism (CD) analyses an...
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| Format: | Article |
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MDPI AG
2018-01-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/16/1/25 |
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| author | Guihong Yu Shuai Wang Lu Wang Qian Che Tianjiao Zhu Guojian Zhang Qianqun Gu Peng Guo Dehai Li |
| author_facet | Guihong Yu Shuai Wang Lu Wang Qian Che Tianjiao Zhu Guojian Zhang Qianqun Gu Peng Guo Dehai Li |
| author_sort | Guihong Yu |
| collection | DOAJ |
| description | Seven new polyketides, named tanzawaic acids R–X (1–6, 11), along with seven known analogues (7–10 and 12–14), were isolated from Penicillium steckii HDN13-279. Their structures, including the absolute configurations, were elucidated by NMR, MS, X-ray diffraction, circular dichroism (CD) analyses and chemical derivatization. Five compounds (2, 3, 6, 10 and 12) significantly decreased the oleic acid (OA)-elicited lipid accumulation in HepG2 liver cells at the concentration of 10 μM, among which, four compounds (3, 6, 10 and 12) significantly decreased intracellular total cholesterol (TC) levels and three Compounds (3, 6, and 10) significantly decreased intracellular triglyceride (TG) levels. Moreover, the TG-lowering capacities of compounds 6 and 10 were comparable with those of simvastatin, with the TG levels being nearly equal to blank control. This is the first report on the lipid-lowering activity of tanzawaic acid derivatives. |
| first_indexed | 2024-04-11T20:42:49Z |
| format | Article |
| id | doaj.art-b96b1c53b9d54deebac35a112568820a |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T20:42:49Z |
| publishDate | 2018-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-b96b1c53b9d54deebac35a112568820a2022-12-22T04:04:10ZengMDPI AGMarine Drugs1660-33972018-01-011612510.3390/md16010025md16010025Lipid-Lowering Polyketides from the Fungus Penicillium Steckii HDN13-279Guihong Yu0Shuai Wang1Lu Wang2Qian Che3Tianjiao Zhu4Guojian Zhang5Qianqun Gu6Peng Guo7Dehai Li8Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaSeven new polyketides, named tanzawaic acids R–X (1–6, 11), along with seven known analogues (7–10 and 12–14), were isolated from Penicillium steckii HDN13-279. Their structures, including the absolute configurations, were elucidated by NMR, MS, X-ray diffraction, circular dichroism (CD) analyses and chemical derivatization. Five compounds (2, 3, 6, 10 and 12) significantly decreased the oleic acid (OA)-elicited lipid accumulation in HepG2 liver cells at the concentration of 10 μM, among which, four compounds (3, 6, 10 and 12) significantly decreased intracellular total cholesterol (TC) levels and three Compounds (3, 6, and 10) significantly decreased intracellular triglyceride (TG) levels. Moreover, the TG-lowering capacities of compounds 6 and 10 were comparable with those of simvastatin, with the TG levels being nearly equal to blank control. This is the first report on the lipid-lowering activity of tanzawaic acid derivatives.http://www.mdpi.com/1660-3397/16/1/25Penicillium steckiitanzawaic acid derivativeslipid-lowering activity |
| spellingShingle | Guihong Yu Shuai Wang Lu Wang Qian Che Tianjiao Zhu Guojian Zhang Qianqun Gu Peng Guo Dehai Li Lipid-Lowering Polyketides from the Fungus Penicillium Steckii HDN13-279 Marine Drugs Penicillium steckii tanzawaic acid derivatives lipid-lowering activity |
| title | Lipid-Lowering Polyketides from the Fungus Penicillium Steckii HDN13-279 |
| title_full | Lipid-Lowering Polyketides from the Fungus Penicillium Steckii HDN13-279 |
| title_fullStr | Lipid-Lowering Polyketides from the Fungus Penicillium Steckii HDN13-279 |
| title_full_unstemmed | Lipid-Lowering Polyketides from the Fungus Penicillium Steckii HDN13-279 |
| title_short | Lipid-Lowering Polyketides from the Fungus Penicillium Steckii HDN13-279 |
| title_sort | lipid lowering polyketides from the fungus penicillium steckii hdn13 279 |
| topic | Penicillium steckii tanzawaic acid derivatives lipid-lowering activity |
| url | http://www.mdpi.com/1660-3397/16/1/25 |
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