Hypothermal opto-thermophoretic tweezers
Abstract Optical tweezers have profound importance across fields ranging from manufacturing to biotechnology. However, the requirement of refractive index contrast and high laser power results in potential photon and thermal damage to the trapped objects, such as nanoparticles and biological cells....
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-08-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-40865-y |
| _version_ | 1797557965040910336 |
|---|---|
| author | Pavana Siddhartha Kollipara Xiuying Li Jingang Li Zhihan Chen Hongru Ding Youngsun Kim Suichu Huang Zhenpeng Qin Yuebing Zheng |
| author_facet | Pavana Siddhartha Kollipara Xiuying Li Jingang Li Zhihan Chen Hongru Ding Youngsun Kim Suichu Huang Zhenpeng Qin Yuebing Zheng |
| author_sort | Pavana Siddhartha Kollipara |
| collection | DOAJ |
| description | Abstract Optical tweezers have profound importance across fields ranging from manufacturing to biotechnology. However, the requirement of refractive index contrast and high laser power results in potential photon and thermal damage to the trapped objects, such as nanoparticles and biological cells. Optothermal tweezers have been developed to trap particles and biological cells via opto-thermophoresis with much lower laser powers. However, the intense laser heating and stringent requirement of the solution environment prevent their use for general biological applications. Here, we propose hypothermal opto-thermophoretic tweezers (HOTTs) to achieve low-power trapping of diverse colloids and biological cells in their native fluids. HOTTs exploit an environmental cooling strategy to simultaneously enhance the thermophoretic trapping force at sub-ambient temperatures and suppress the thermal damage to target objects. We further apply HOTTs to demonstrate the three-dimensional manipulation of functional plasmonic vesicles for controlled cargo delivery. With their noninvasiveness and versatile capabilities, HOTTs present a promising tool for fundamental studies and practical applications in materials science and biotechnology. |
| first_indexed | 2024-03-10T17:23:41Z |
| format | Article |
| id | doaj.art-b96d1faee1454b99b73edc8966c35f09 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-10T17:23:41Z |
| publishDate | 2023-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b96d1faee1454b99b73edc8966c35f092023-11-20T10:15:14ZengNature PortfolioNature Communications2041-17232023-08-011411910.1038/s41467-023-40865-yHypothermal opto-thermophoretic tweezersPavana Siddhartha Kollipara0Xiuying Li1Jingang Li2Zhihan Chen3Hongru Ding4Youngsun Kim5Suichu Huang6Zhenpeng Qin7Yuebing Zheng8Walker Department of Mechanical Engineering, The University of Texas at AustinDepartment of Mechanical Engineering, The University of Texas at DallasMaterials Science and Engineering Program and Texas Materials Institute, The University of Texas at AustinMaterials Science and Engineering Program and Texas Materials Institute, The University of Texas at AustinWalker Department of Mechanical Engineering, The University of Texas at AustinMaterials Science and Engineering Program and Texas Materials Institute, The University of Texas at AustinKey Laboratory of Micro-Systems and Micro-Structures Manufacturing of Ministry of Education and School of Mechatronics Engineering, Harbin Institute of TechnologyDepartment of Mechanical Engineering, The University of Texas at DallasWalker Department of Mechanical Engineering, The University of Texas at AustinAbstract Optical tweezers have profound importance across fields ranging from manufacturing to biotechnology. However, the requirement of refractive index contrast and high laser power results in potential photon and thermal damage to the trapped objects, such as nanoparticles and biological cells. Optothermal tweezers have been developed to trap particles and biological cells via opto-thermophoresis with much lower laser powers. However, the intense laser heating and stringent requirement of the solution environment prevent their use for general biological applications. Here, we propose hypothermal opto-thermophoretic tweezers (HOTTs) to achieve low-power trapping of diverse colloids and biological cells in their native fluids. HOTTs exploit an environmental cooling strategy to simultaneously enhance the thermophoretic trapping force at sub-ambient temperatures and suppress the thermal damage to target objects. We further apply HOTTs to demonstrate the three-dimensional manipulation of functional plasmonic vesicles for controlled cargo delivery. With their noninvasiveness and versatile capabilities, HOTTs present a promising tool for fundamental studies and practical applications in materials science and biotechnology.https://doi.org/10.1038/s41467-023-40865-y |
| spellingShingle | Pavana Siddhartha Kollipara Xiuying Li Jingang Li Zhihan Chen Hongru Ding Youngsun Kim Suichu Huang Zhenpeng Qin Yuebing Zheng Hypothermal opto-thermophoretic tweezers Nature Communications |
| title | Hypothermal opto-thermophoretic tweezers |
| title_full | Hypothermal opto-thermophoretic tweezers |
| title_fullStr | Hypothermal opto-thermophoretic tweezers |
| title_full_unstemmed | Hypothermal opto-thermophoretic tweezers |
| title_short | Hypothermal opto-thermophoretic tweezers |
| title_sort | hypothermal opto thermophoretic tweezers |
| url | https://doi.org/10.1038/s41467-023-40865-y |
| work_keys_str_mv | AT pavanasiddharthakollipara hypothermaloptothermophoretictweezers AT xiuyingli hypothermaloptothermophoretictweezers AT jingangli hypothermaloptothermophoretictweezers AT zhihanchen hypothermaloptothermophoretictweezers AT hongruding hypothermaloptothermophoretictweezers AT youngsunkim hypothermaloptothermophoretictweezers AT suichuhuang hypothermaloptothermophoretictweezers AT zhenpengqin hypothermaloptothermophoretictweezers AT yuebingzheng hypothermaloptothermophoretictweezers |