Binding Studies on Isolated Porcine Small Intestinal Mucosa and in vitro Toxicity Studies Reveal Lack of Effect of C. perfringens Beta-Toxin on the Porcine Intestinal Epithelium

Binding Studies on Isolated Porcine Small Intestinal Mucosa and in vitro Toxicity Studies Reveal Lack of Effect of C. perfringens Beta-Toxin on the Porcine Intestinal Epithelium

Beta-toxin (CPB) is the essential virulence factor of C. perfringens type C causing necrotizing enteritis (NE) in different hosts. Using a pig infection model, we showed that CPB targets small intestinal endothelial cells. Its effect on the porcine intestinal epithelium, however, could not be ade...

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Bibliographic Details
Main Authors: Simone Roos, Marianne Wyder, Ahmet Candi, Nadine Regenscheit, Christina Nathues, Filip van Immerseel, Horst Posthaus
Format: Article
Language:English
Published: MDPI AG 2015-04-01
Series:Toxins
Subjects:
Clostridium perfringens type C
beta-toxin
endothelium
mucosa
epithelium
pathogenesis
porcine
Online Access:http://www.mdpi.com/2072-6651/7/4/1235

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