Drimane Sesquiterpene-Conjugated Amino Acids from a Marine Isolate of the Fungus Talaromyces minioluteus (Penicillium Minioluteum)

Drimane Sesquiterpene-Conjugated Amino Acids from a Marine Isolate of the Fungus Talaromyces minioluteus (Penicillium Minioluteum)

Four new sesquiterpene lactones (3, 4, 6 and 7) and three known compounds, purpuride (1), berkedrimane B (2) and purpuride B (5), were isolated from the marine fungus, Talaromyces minioluteus (Penicillium minioluteum). New compounds were drimane sesquiterpenes conjugated with N-acetyl-l-valine, and...

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Bibliographic Details
Main Authors: Suthatip Ngokpol, Wittaya Suwakulsiri, Sanya Sureram, Kriengsak Lirdprapamongkol, Thammarat Aree, Suthep Wiyakrutta, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:Marine Drugs
Subjects:
marine fungi
Talaromyces minioluteus
Penicillium minioluteum
sesquiterpene
drimane
caspase-3
cytotoxic activity
fungal metabolites
Online Access:http://www.mdpi.com/1660-3397/13/6/3567
Description
Summary:Four new sesquiterpene lactones (3, 4, 6 and 7) and three known compounds, purpuride (1), berkedrimane B (2) and purpuride B (5), were isolated from the marine fungus, Talaromyces minioluteus (Penicillium minioluteum). New compounds were drimane sesquiterpenes conjugated with N-acetyl-l-valine, and their structures were elucidated by analysis of spectroscopic data, as well as by single crystal X-ray analysis. The isolated compounds could not inhibit the apoptosis-regulating enzyme, caspase-3, while three of the compounds (2, 3 and 7) exhibited weak cytotoxic activity.
ISSN:1660-3397

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