Drimane Sesquiterpene-Conjugated Amino Acids from a Marine Isolate of the Fungus Talaromyces minioluteus (Penicillium Minioluteum)
Four new sesquiterpene lactones (3, 4, 6 and 7) and three known compounds, purpuride (1), berkedrimane B (2) and purpuride B (5), were isolated from the marine fungus, Talaromyces minioluteus (Penicillium minioluteum). New compounds were drimane sesquiterpenes conjugated with N-acetyl-l-valine, and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-06-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/13/6/3567 |
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| author | Suthatip Ngokpol Wittaya Suwakulsiri Sanya Sureram Kriengsak Lirdprapamongkol Thammarat Aree Suthep Wiyakrutta Chulabhorn Mahidol Somsak Ruchirawat Prasat Kittakoop |
| author_facet | Suthatip Ngokpol Wittaya Suwakulsiri Sanya Sureram Kriengsak Lirdprapamongkol Thammarat Aree Suthep Wiyakrutta Chulabhorn Mahidol Somsak Ruchirawat Prasat Kittakoop |
| author_sort | Suthatip Ngokpol |
| collection | DOAJ |
| description | Four new sesquiterpene lactones (3, 4, 6 and 7) and three known compounds, purpuride (1), berkedrimane B (2) and purpuride B (5), were isolated from the marine fungus, Talaromyces minioluteus (Penicillium minioluteum). New compounds were drimane sesquiterpenes conjugated with N-acetyl-l-valine, and their structures were elucidated by analysis of spectroscopic data, as well as by single crystal X-ray analysis. The isolated compounds could not inhibit the apoptosis-regulating enzyme, caspase-3, while three of the compounds (2, 3 and 7) exhibited weak cytotoxic activity. |
| first_indexed | 2024-04-13T08:33:46Z |
| format | Article |
| id | doaj.art-b96dcacccc6d4e2f83ed7d0287ea338d |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-13T08:33:46Z |
| publishDate | 2015-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-b96dcacccc6d4e2f83ed7d0287ea338d2022-12-22T02:54:11ZengMDPI AGMarine Drugs1660-33972015-06-011363567358010.3390/md13063567md13063567Drimane Sesquiterpene-Conjugated Amino Acids from a Marine Isolate of the Fungus Talaromyces minioluteus (Penicillium Minioluteum)Suthatip Ngokpol0Wittaya Suwakulsiri1Sanya Sureram2Kriengsak Lirdprapamongkol3Thammarat Aree4Suthep Wiyakrutta5Chulabhorn Mahidol6Somsak Ruchirawat7Prasat Kittakoop8Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, ThailandChulabhorn Graduate Institute, Chemical Biology Program, Laksi, Bangkok 10210, ThailandChulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, ThailandChulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, ThailandDepartment of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, ThailandDepartment of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, ThailandChulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, ThailandChulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, ThailandChulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, ThailandFour new sesquiterpene lactones (3, 4, 6 and 7) and three known compounds, purpuride (1), berkedrimane B (2) and purpuride B (5), were isolated from the marine fungus, Talaromyces minioluteus (Penicillium minioluteum). New compounds were drimane sesquiterpenes conjugated with N-acetyl-l-valine, and their structures were elucidated by analysis of spectroscopic data, as well as by single crystal X-ray analysis. The isolated compounds could not inhibit the apoptosis-regulating enzyme, caspase-3, while three of the compounds (2, 3 and 7) exhibited weak cytotoxic activity.http://www.mdpi.com/1660-3397/13/6/3567marine fungiTalaromyces minioluteus Penicillium minioluteumsesquiterpenedrimanecaspase-3cytotoxic activityfungal metabolites |
| spellingShingle | Suthatip Ngokpol Wittaya Suwakulsiri Sanya Sureram Kriengsak Lirdprapamongkol Thammarat Aree Suthep Wiyakrutta Chulabhorn Mahidol Somsak Ruchirawat Prasat Kittakoop Drimane Sesquiterpene-Conjugated Amino Acids from a Marine Isolate of the Fungus Talaromyces minioluteus (Penicillium Minioluteum) Marine Drugs marine fungi Talaromyces minioluteus Penicillium minioluteum sesquiterpene drimane caspase-3 cytotoxic activity fungal metabolites |
| title | Drimane Sesquiterpene-Conjugated Amino Acids from a Marine Isolate of the Fungus Talaromyces minioluteus (Penicillium Minioluteum) |
| title_full | Drimane Sesquiterpene-Conjugated Amino Acids from a Marine Isolate of the Fungus Talaromyces minioluteus (Penicillium Minioluteum) |
| title_fullStr | Drimane Sesquiterpene-Conjugated Amino Acids from a Marine Isolate of the Fungus Talaromyces minioluteus (Penicillium Minioluteum) |
| title_full_unstemmed | Drimane Sesquiterpene-Conjugated Amino Acids from a Marine Isolate of the Fungus Talaromyces minioluteus (Penicillium Minioluteum) |
| title_short | Drimane Sesquiterpene-Conjugated Amino Acids from a Marine Isolate of the Fungus Talaromyces minioluteus (Penicillium Minioluteum) |
| title_sort | drimane sesquiterpene conjugated amino acids from a marine isolate of the fungus talaromyces minioluteus penicillium minioluteum |
| topic | marine fungi Talaromyces minioluteus Penicillium minioluteum sesquiterpene drimane caspase-3 cytotoxic activity fungal metabolites |
| url | http://www.mdpi.com/1660-3397/13/6/3567 |
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