Immunoregulatory functions and therapeutic potential of natural killer cell-derived extracellular vesicles in chronic diseases
Extracellular vesicles (EVs) have been proven to play a significant immunoregulatory role in many chronic diseases, such as cancer and immune disorders. Among them, EVs derived from NK cells are an essential component of the immune cell functions. These EVs have been demonstrated to carry a variety...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1328094/full |
| _version_ | 1827391962040238080 |
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| author | Shuang He Shuang He Lanqian Su Haiyang Hu Haiqi Liu Jingwen Xiong Xiangjin Gong Hao Chi Qibiao Wu Guanhu Yang |
| author_facet | Shuang He Shuang He Lanqian Su Haiyang Hu Haiqi Liu Jingwen Xiong Xiangjin Gong Hao Chi Qibiao Wu Guanhu Yang |
| author_sort | Shuang He |
| collection | DOAJ |
| description | Extracellular vesicles (EVs) have been proven to play a significant immunoregulatory role in many chronic diseases, such as cancer and immune disorders. Among them, EVs derived from NK cells are an essential component of the immune cell functions. These EVs have been demonstrated to carry a variety of toxic proteins and nucleic acids derived from NK cells and play a therapeutic role in diseases like malignancies, liver fibrosis, and lung injury. However, natural NK-derived EVs (NKEVs) have certain limitations in disease treatment, such as low yield and poor targeting. Concurrently, NK cells exhibit characteristics of memory-like NK cells, which have stronger proliferative capacity, increased IFN-γ production, and enhanced cytotoxicity, making them more advantageous for disease treatment. Recent research has shifted its focus towards engineered extracellular vesicles and their potential to improve the efficiency, specificity, and safety of disease treatments. In this review, we will discuss the characteristics of NK-derived EVs and the latest advancements in disease therapy. Specifically, we will compare different cellular sources of NKEVs and explore the current status and prospects of memory-like NK cell-derived EVs and engineered NKEVs. |
| first_indexed | 2024-03-08T17:23:00Z |
| format | Article |
| id | doaj.art-b96fb96b4bdf4b69a72c67a7e8aeb8a1 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T17:23:00Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b96fb96b4bdf4b69a72c67a7e8aeb8a12024-01-03T04:13:54ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-01-011410.3389/fimmu.2023.13280941328094Immunoregulatory functions and therapeutic potential of natural killer cell-derived extracellular vesicles in chronic diseasesShuang He0Shuang He1Lanqian Su2Haiyang Hu3Haiqi Liu4Jingwen Xiong5Xiangjin Gong6Hao Chi7Qibiao Wu8Guanhu Yang9Faculty of Chinese Medicine, and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao, Macao SAR, ChinaClinical Medical College, Southwest Medical University, Luzhou, ChinaClinical Medical College, Southwest Medical University, Luzhou, ChinaClinical Medical College, Southwest Medical University, Luzhou, ChinaClinical Medical College, Southwest Medical University, Luzhou, ChinaDepartment of Sports Rehabilitation, Southwest Medical University, Luzhou, ChinaDepartment of Sports Rehabilitation, Southwest Medical University, Luzhou, ChinaClinical Medical College, Southwest Medical University, Luzhou, ChinaFaculty of Chinese Medicine, and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao, Macao SAR, ChinaDepartment of Specialty Medicine, Ohio University, Athens, OH, United StatesExtracellular vesicles (EVs) have been proven to play a significant immunoregulatory role in many chronic diseases, such as cancer and immune disorders. Among them, EVs derived from NK cells are an essential component of the immune cell functions. These EVs have been demonstrated to carry a variety of toxic proteins and nucleic acids derived from NK cells and play a therapeutic role in diseases like malignancies, liver fibrosis, and lung injury. However, natural NK-derived EVs (NKEVs) have certain limitations in disease treatment, such as low yield and poor targeting. Concurrently, NK cells exhibit characteristics of memory-like NK cells, which have stronger proliferative capacity, increased IFN-γ production, and enhanced cytotoxicity, making them more advantageous for disease treatment. Recent research has shifted its focus towards engineered extracellular vesicles and their potential to improve the efficiency, specificity, and safety of disease treatments. In this review, we will discuss the characteristics of NK-derived EVs and the latest advancements in disease therapy. Specifically, we will compare different cellular sources of NKEVs and explore the current status and prospects of memory-like NK cell-derived EVs and engineered NKEVs.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1328094/fullNK cellNK cell-derived exosomeengineered EVschronic diseasemicrovesiclestherapy |
| spellingShingle | Shuang He Shuang He Lanqian Su Haiyang Hu Haiqi Liu Jingwen Xiong Xiangjin Gong Hao Chi Qibiao Wu Guanhu Yang Immunoregulatory functions and therapeutic potential of natural killer cell-derived extracellular vesicles in chronic diseases Frontiers in Immunology NK cell NK cell-derived exosome engineered EVs chronic disease microvesicles therapy |
| title | Immunoregulatory functions and therapeutic potential of natural killer cell-derived extracellular vesicles in chronic diseases |
| title_full | Immunoregulatory functions and therapeutic potential of natural killer cell-derived extracellular vesicles in chronic diseases |
| title_fullStr | Immunoregulatory functions and therapeutic potential of natural killer cell-derived extracellular vesicles in chronic diseases |
| title_full_unstemmed | Immunoregulatory functions and therapeutic potential of natural killer cell-derived extracellular vesicles in chronic diseases |
| title_short | Immunoregulatory functions and therapeutic potential of natural killer cell-derived extracellular vesicles in chronic diseases |
| title_sort | immunoregulatory functions and therapeutic potential of natural killer cell derived extracellular vesicles in chronic diseases |
| topic | NK cell NK cell-derived exosome engineered EVs chronic disease microvesicles therapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1328094/full |
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