A tandem CD19/CD20 CAR lentiviral vector drives on-target and off-target antigen modulation in leukemia cell lines

A tandem CD19/CD20 CAR lentiviral vector drives on-target and off-target antigen modulation in leukemia cell lines

Abstract Background Clinical success with chimeric antigen receptor (CAR)- based immunotherapy for leukemia has been accompanied by the associated finding that antigen-escape variants of the disease are responsible for relapse. To target hematologic malignancies with a chimeric antigen receptor (CAR...

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Bibliographic Details
Main Authors: Dina Schneider, Ying Xiong, Darong Wu, Volker Nӧlle, Sarah Schmitz, Waleed Haso, Andrew Kaiser, Boro Dropulic, Rimas J. Orentas
Format: Article
Language:English
Published: BMJ Publishing Group 2017-05-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
CAR T
Tandem -targeting CAR
Lentiviral vector
Adoptive immunotherapy
Hematologic malignancy
Tumor antigen escape
Online Access:http://link.springer.com/article/10.1186/s40425-017-0246-1

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