DNA methylation profiling reveals a pathological signature that contributes to transcriptional defects of CD34+CD15− cells in early chronic‐phase chronic myeloid leukemia

DNA methylation profiling reveals a pathological signature that contributes to transcriptional defects of CD34+CD15− cells in early chronic‐phase chronic myeloid leukemia

Despite the high efficiency of tyrosine kinase inhibitors (TKI), some patients with chronic myeloid leukemia (CML) will display residual disease that can become resistant to treatment, indicating intraclonal heterogeneity in chronic‐phase CML (CP‐CML). To determine the basis of this heterogeneity, w...

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Bibliographic Details
Main Authors: Stéphanie Maupetit‐Mehouas, Franck Court, Céline Bourgne, Agnès Guerci‐Bresler, Pascale Cony‐Makhoul, Hyacinthe Johnson, Gabriel Etienne, Philippe Rousselot, Denis Guyotat, Alexandre Janel, Eric Hermet, Sandrine Saugues, Juliette Berger, Philippe Arnaud, Marc G. Berger
Format: Article
Language:English
Published: Wiley 2018-06-01
Series:Molecular Oncology
Subjects:
CML
DNA methylation
epigenetics
leukemic stem cells
transcriptional defects
Online Access:https://doi.org/10.1002/1878-0261.12191

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