Mice with altered BDNF signaling as models for mood disorders and antidepressant effects

Mice with altered BDNF signaling as models for mood disorders and antidepressant effects

Brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase TrkB support neuronal survival during development and promote connectivity and plasticity in the adult brain. Decreased BDNF signaling is associated with the pathophysiology of depression and the mechanisms underlying the acti...

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Bibliographic Details
Main Authors: Jesse Saku Olavi Lindholm, Eero eCastrén
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-04-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Anxiety
Behavior
Depression
BDNF
transgenic
neurotrophins
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00143/full

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