Calorie Restriction Using High-Fat/Low-Carbohydrate Diet Suppresses Liver Fat Accumulation and Pancreatic Beta-Cell Dedifferentiation in Obese Diabetic Mice

Calorie Restriction Using High-Fat/Low-Carbohydrate Diet Suppresses Liver Fat Accumulation and Pancreatic Beta-Cell Dedifferentiation in Obese Diabetic Mice

In diabetes, pancreatic β-cells gradually lose their ability to secrete insulin with disease progression. β-cell dysfunction is a contributing factor to diabetes severity. Recently, islet cell heterogeneity, exemplified by β-cell dedifferentiation and identified in diabetic animals, has attracted at...

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Bibliographic Details
Main Authors:	Xiao Lei, Emi Ishida, Satoshi Yoshino, Shunichi Matsumoto, Kazuhiko Horiguchi, Eijiro Yamada
Format:	Article
Language:	English
Published:	MDPI AG 2024-03-01
Series:	Nutrients
Subjects:	diabetes dyslipidemia obesity <i>db</i>/<i>db</i> mice calorie restriction carbohydrate/fat ratio
Online Access:	https://www.mdpi.com/2072-6643/16/7/995

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