Topical Chinese herbal compound in the treatment of oral candidiasis: A systematic review and meta-analysis of randomized controlled trials
Objective: A meta-analysis was performed to systematically review the clinical efficacy of external traditional Chinese medicine compounds in the treatment of oral candidiasis to provide a reference for the clinical treatment of this disease. Methods: We systematically searched relevant Chinese and...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-02-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023004607 |
| _version_ | 1811161862587285504 |
|---|---|
| author | Ting Li Qiaoyu Hu Jiadi Yang Nan Zhang Na Liu Qing Liu |
| author_facet | Ting Li Qiaoyu Hu Jiadi Yang Nan Zhang Na Liu Qing Liu |
| author_sort | Ting Li |
| collection | DOAJ |
| description | Objective: A meta-analysis was performed to systematically review the clinical efficacy of external traditional Chinese medicine compounds in the treatment of oral candidiasis to provide a reference for the clinical treatment of this disease. Methods: We systematically searched relevant Chinese and English databases, including the Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Chinese Scientific Journal Database, Wanfang Database, PubMed, Web of Science, the Cochrane Library and Scopus, from inception to September 2022 to identify all clinical randomized controlled studies of oral candidiasis treated with external Chinese medicine compounds. The inclusion criteria were a randomized controlled study of an experimental group with the intervention of an external traditional Chinese medicine compound, and the results of the literature were clear. Duplicate publications, literature on single or proprietary Chinese medicine treatment, literature from which relevant data could not be extracted and studies without rigorous experimental designs were excluded. Two researchers independently screened relevant studies that met the inclusion and exclusion criteria and conducted quality evaluation and data extraction for the included studies. The total effective rate, Candida negative conversion rate and recurrence rate were statistically analysed by RevMan 5.3 software. Results: This study included 29 studies and 30 studies, involving 2553 patients with oral candidiasis, with 1320 in the experimental group and 1233 in the control group. The total effective rate of the experimental group was better than that of the control group (RR = 1.21 [1.15, 1.27], P < 0.000). The negative rate of Candida in the experimental group was better than that in the control group (RR = 1.25 [1.05, 1.50], P=0.01). The recurrence rate of the experimental group was lower than that of the control group (RR = 0.34 [0.18, 0.63], P=0.0007). The difference was statistically significant. Conclusion: Compared with Western medicine alone, external traditional Chinese medicine in the treatment of oral candidiasis has certain advantages in improving the total effective rate, increasing the negative conversion rate of Candida and reducing the recurrence rate. However, larger samples and high-quality clinical studies are needed to obtain further support and verification. |
| first_indexed | 2024-04-10T06:20:53Z |
| format | Article |
| id | doaj.art-b9761d65df2b4cdeb28a163b2215ed6f |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-10T06:20:53Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-b9761d65df2b4cdeb28a163b2215ed6f2023-03-02T05:00:41ZengElsevierHeliyon2405-84402023-02-0192e13253Topical Chinese herbal compound in the treatment of oral candidiasis: A systematic review and meta-analysis of randomized controlled trialsTing Li0Qiaoyu Hu1Jiadi Yang2Nan Zhang3Na Liu4Qing Liu5Hebei Key Laboratory of Stomatology, Hebei Clinical Research Center for Oral Diseases, School and Hospital of Stomatology, Hebei Medical University, Shijiazhuang, 050017, ChinaHebei Key Laboratory of Stomatology, Hebei Clinical Research Center for Oral Diseases, School and Hospital of Stomatology, Hebei Medical University, Shijiazhuang, 050017, ChinaHebei Key Laboratory of Stomatology, Hebei Clinical Research Center for Oral Diseases, School and Hospital of Stomatology, Hebei Medical University, Shijiazhuang, 050017, ChinaDepartment of Stomatology, Shanxi Bethune Hospital, Third Hospital of Shanxi Medical University, ChinaDepartment of Preventive Dentistry, School and Hospital of Stomatology, Hebei Medical University, Shijiazhuang, 050017, China; Corresponding author. Department of Preventive Dentistry, School and Hospital of Stomatology, Hebei Medical University, No. 383, Zhongshan East Road, Shijiazhuang 050017, PR China.Hebei Key Laboratory of Stomatology, Hebei Clinical Research Center for Oral Diseases, School and Hospital of Stomatology, Hebei Medical University, Shijiazhuang, 050017, China; Corresponding author. Hebei Key Laboratory of Stomatology, Hebei Clinical Research Center for Oral Diseases, School and Hospital of Stomatology, Hebei Medical University, No. 383, Zhongshan East Road, Shijiazhuang 050017, PR China.Objective: A meta-analysis was performed to systematically review the clinical efficacy of external traditional Chinese medicine compounds in the treatment of oral candidiasis to provide a reference for the clinical treatment of this disease. Methods: We systematically searched relevant Chinese and English databases, including the Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Chinese Scientific Journal Database, Wanfang Database, PubMed, Web of Science, the Cochrane Library and Scopus, from inception to September 2022 to identify all clinical randomized controlled studies of oral candidiasis treated with external Chinese medicine compounds. The inclusion criteria were a randomized controlled study of an experimental group with the intervention of an external traditional Chinese medicine compound, and the results of the literature were clear. Duplicate publications, literature on single or proprietary Chinese medicine treatment, literature from which relevant data could not be extracted and studies without rigorous experimental designs were excluded. Two researchers independently screened relevant studies that met the inclusion and exclusion criteria and conducted quality evaluation and data extraction for the included studies. The total effective rate, Candida negative conversion rate and recurrence rate were statistically analysed by RevMan 5.3 software. Results: This study included 29 studies and 30 studies, involving 2553 patients with oral candidiasis, with 1320 in the experimental group and 1233 in the control group. The total effective rate of the experimental group was better than that of the control group (RR = 1.21 [1.15, 1.27], P < 0.000). The negative rate of Candida in the experimental group was better than that in the control group (RR = 1.25 [1.05, 1.50], P=0.01). The recurrence rate of the experimental group was lower than that of the control group (RR = 0.34 [0.18, 0.63], P=0.0007). The difference was statistically significant. Conclusion: Compared with Western medicine alone, external traditional Chinese medicine in the treatment of oral candidiasis has certain advantages in improving the total effective rate, increasing the negative conversion rate of Candida and reducing the recurrence rate. However, larger samples and high-quality clinical studies are needed to obtain further support and verification.http://www.sciencedirect.com/science/article/pii/S2405844023004607Topical Chinese herbal compoundOral candidiasisMeta-analysisSystemic review |
| spellingShingle | Ting Li Qiaoyu Hu Jiadi Yang Nan Zhang Na Liu Qing Liu Topical Chinese herbal compound in the treatment of oral candidiasis: A systematic review and meta-analysis of randomized controlled trials Heliyon Topical Chinese herbal compound Oral candidiasis Meta-analysis Systemic review |
| title | Topical Chinese herbal compound in the treatment of oral candidiasis: A systematic review and meta-analysis of randomized controlled trials |
| title_full | Topical Chinese herbal compound in the treatment of oral candidiasis: A systematic review and meta-analysis of randomized controlled trials |
| title_fullStr | Topical Chinese herbal compound in the treatment of oral candidiasis: A systematic review and meta-analysis of randomized controlled trials |
| title_full_unstemmed | Topical Chinese herbal compound in the treatment of oral candidiasis: A systematic review and meta-analysis of randomized controlled trials |
| title_short | Topical Chinese herbal compound in the treatment of oral candidiasis: A systematic review and meta-analysis of randomized controlled trials |
| title_sort | topical chinese herbal compound in the treatment of oral candidiasis a systematic review and meta analysis of randomized controlled trials |
| topic | Topical Chinese herbal compound Oral candidiasis Meta-analysis Systemic review |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023004607 |
| work_keys_str_mv | AT tingli topicalchineseherbalcompoundinthetreatmentoforalcandidiasisasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT qiaoyuhu topicalchineseherbalcompoundinthetreatmentoforalcandidiasisasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT jiadiyang topicalchineseherbalcompoundinthetreatmentoforalcandidiasisasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT nanzhang topicalchineseherbalcompoundinthetreatmentoforalcandidiasisasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT naliu topicalchineseherbalcompoundinthetreatmentoforalcandidiasisasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT qingliu topicalchineseherbalcompoundinthetreatmentoforalcandidiasisasystematicreviewandmetaanalysisofrandomizedcontrolledtrials |