The Release of Immunosuppressive Factor(s) in Young Males Following Exercise
It has been shown that a suppressive protein, acting as an immune suppressor, is generated in animals and humans under particular stresses. However, studies related to immunosuppressive factors in response to the stress resulting from acute exercise are limited. This study compares the effects of pr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-05-01
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| Series: | Sensors |
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| Online Access: | http://www.mdpi.com/1424-8220/12/5/5586 |
| _version_ | 1811186370374270976 |
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| author | Julien S. Baker Ye Tian Jinlei Nie Tom K. Tong |
| author_facet | Julien S. Baker Ye Tian Jinlei Nie Tom K. Tong |
| author_sort | Julien S. Baker |
| collection | DOAJ |
| description | It has been shown that a suppressive protein, acting as an immune suppressor, is generated in animals and humans under particular stresses. However, studies related to immunosuppressive factors in response to the stress resulting from acute exercise are limited. This study compares the effects of pre- and post-exercise human serum on concanavalin A stimulated lymphocyte proliferation of mice. In the present study, blood samples in eight male undergraduates (age 21 ± 0.7 years) were taken before and immediately after ten sets of exercise consisting of 15 free and 30 10-kg loaded squat jumps in each set. The suppression of lymphocyte proliferation was analysed with high pressure liquid chromatography. It was noted from the result of gel chromatography columns that the post-exercise values of the suppression of lymphocyte proliferation, in comparison to corresponding pre-exercise values, were generally greater with significant differences observed in 7.5th–9th min post-exercise eluates (P < 0.05). Such findings suggest that intense eccentric type exercise may lead to generation of immunosuppressive factor(s) in young males. |
| first_indexed | 2024-04-11T13:44:25Z |
| format | Article |
| id | doaj.art-b979c77abe34400e90c268698ed8c164 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-11T13:44:25Z |
| publishDate | 2012-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-b979c77abe34400e90c268698ed8c1642022-12-22T04:21:08ZengMDPI AGSensors1424-82202012-05-011255586559510.3390/s120505586The Release of Immunosuppressive Factor(s) in Young Males Following ExerciseJulien S. BakerYe TianJinlei NieTom K. TongIt has been shown that a suppressive protein, acting as an immune suppressor, is generated in animals and humans under particular stresses. However, studies related to immunosuppressive factors in response to the stress resulting from acute exercise are limited. This study compares the effects of pre- and post-exercise human serum on concanavalin A stimulated lymphocyte proliferation of mice. In the present study, blood samples in eight male undergraduates (age 21 ± 0.7 years) were taken before and immediately after ten sets of exercise consisting of 15 free and 30 10-kg loaded squat jumps in each set. The suppression of lymphocyte proliferation was analysed with high pressure liquid chromatography. It was noted from the result of gel chromatography columns that the post-exercise values of the suppression of lymphocyte proliferation, in comparison to corresponding pre-exercise values, were generally greater with significant differences observed in 7.5th–9th min post-exercise eluates (P < 0.05). Such findings suggest that intense eccentric type exercise may lead to generation of immunosuppressive factor(s) in young males.http://www.mdpi.com/1424-8220/12/5/5586exerciseimmunosuppressive factordelayed onset muscle soreness |
| spellingShingle | Julien S. Baker Ye Tian Jinlei Nie Tom K. Tong The Release of Immunosuppressive Factor(s) in Young Males Following Exercise Sensors exercise immunosuppressive factor delayed onset muscle soreness |
| title | The Release of Immunosuppressive Factor(s) in Young Males Following Exercise |
| title_full | The Release of Immunosuppressive Factor(s) in Young Males Following Exercise |
| title_fullStr | The Release of Immunosuppressive Factor(s) in Young Males Following Exercise |
| title_full_unstemmed | The Release of Immunosuppressive Factor(s) in Young Males Following Exercise |
| title_short | The Release of Immunosuppressive Factor(s) in Young Males Following Exercise |
| title_sort | release of immunosuppressive factor s in young males following exercise |
| topic | exercise immunosuppressive factor delayed onset muscle soreness |
| url | http://www.mdpi.com/1424-8220/12/5/5586 |
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