Orexin system and pathogenesis of sleep-wake cycle disturbances in narcolepsy
Sleep is the one of the most important vital functions of the body. The study of the primary mechanisms that result in disturbance of the sleep-wake cycle is a priority of modern medical science. It is known that the orexin neurons of the hypothalamus, which send projections to all waking centers, p...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2018-01-01
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| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/1020 |
| _version_ | 1797872924829417472 |
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| author | Yu. V. Gavrilov K. Z. Derevtsova H. A. Korneva |
| author_facet | Yu. V. Gavrilov K. Z. Derevtsova H. A. Korneva |
| author_sort | Yu. V. Gavrilov |
| collection | DOAJ |
| description | Sleep is the one of the most important vital functions of the body. The study of the primary mechanisms that result in disturbance of the sleep-wake cycle is a priority of modern medical science. It is known that the orexin neurons of the hypothalamus, which send projections to all waking centers, play a leading role in initiating and maintaining this state. Insufficiency of the function of the orexinergic system of the hypothalamus leads to disturbances in the sleep-wake cycle and the development of the severe diseases of narcolepsy and cataplexy. The presented review is devoted to the investigation of possible mechanisms of development of pathological changes in the orexin-containing neurons functions and the diseases caused by them. |
| first_indexed | 2024-04-10T01:06:44Z |
| format | Article |
| id | doaj.art-b97a97f7b19643f5b24990dfa5ef0fe6 |
| institution | Directory Open Access Journal |
| issn | 1682-0363 1819-3684 |
| language | English |
| last_indexed | 2024-04-10T01:06:44Z |
| publishDate | 2018-01-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj.art-b97a97f7b19643f5b24990dfa5ef0fe62023-03-13T09:58:23ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842018-01-0116471510.20538/1682-0363-2017-4-7-15728Orexin system and pathogenesis of sleep-wake cycle disturbances in narcolepsyYu. V. Gavrilov0K. Z. Derevtsova1H. A. Korneva2Институт экспериментальной медицины (ИЭМ)Институт экспериментальной медицины (ИЭМ)Институт экспериментальной медицины (ИЭМ); Санкт-Петербургский государственный университетSleep is the one of the most important vital functions of the body. The study of the primary mechanisms that result in disturbance of the sleep-wake cycle is a priority of modern medical science. It is known that the orexin neurons of the hypothalamus, which send projections to all waking centers, play a leading role in initiating and maintaining this state. Insufficiency of the function of the orexinergic system of the hypothalamus leads to disturbances in the sleep-wake cycle and the development of the severe diseases of narcolepsy and cataplexy. The presented review is devoted to the investigation of possible mechanisms of development of pathological changes in the orexin-containing neurons functions and the diseases caused by them.https://bulletin.ssmu.ru/jour/article/view/1020нарколепсиякатаплексияорексинсонбодрствование |
| spellingShingle | Yu. V. Gavrilov K. Z. Derevtsova H. A. Korneva Orexin system and pathogenesis of sleep-wake cycle disturbances in narcolepsy Бюллетень сибирской медицины нарколепсия катаплексия орексин сон бодрствование |
| title | Orexin system and pathogenesis of sleep-wake cycle disturbances in narcolepsy |
| title_full | Orexin system and pathogenesis of sleep-wake cycle disturbances in narcolepsy |
| title_fullStr | Orexin system and pathogenesis of sleep-wake cycle disturbances in narcolepsy |
| title_full_unstemmed | Orexin system and pathogenesis of sleep-wake cycle disturbances in narcolepsy |
| title_short | Orexin system and pathogenesis of sleep-wake cycle disturbances in narcolepsy |
| title_sort | orexin system and pathogenesis of sleep wake cycle disturbances in narcolepsy |
| topic | нарколепсия катаплексия орексин сон бодрствование |
| url | https://bulletin.ssmu.ru/jour/article/view/1020 |
| work_keys_str_mv | AT yuvgavrilov orexinsystemandpathogenesisofsleepwakecycledisturbancesinnarcolepsy AT kzderevtsova orexinsystemandpathogenesisofsleepwakecycledisturbancesinnarcolepsy AT hakorneva orexinsystemandpathogenesisofsleepwakecycledisturbancesinnarcolepsy |