Efficacy of continuous positive airway pressure on NT-pro-BNP in obstructive sleep apnea patients: a meta-analysis
Abstract Background N-terminal probrain natriuretic peptide (NT-pro-BNP) and BNP are well-known markers for the diagnosis and prognostic of heart failure. Until now, it was not clear whether BNP levels are influenced by events occurring within Obstructive sleep apnea–hypopnea syndrome (OSAHS) with c...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | https://doi.org/10.1186/s12890-023-02539-9 |
| _version_ | 1797779074154758144 |
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| author | Qinqin Wu Xiaojun Ma Yanyan Wang Jianfeng Jin Jia Li Shuming Guo |
| author_facet | Qinqin Wu Xiaojun Ma Yanyan Wang Jianfeng Jin Jia Li Shuming Guo |
| author_sort | Qinqin Wu |
| collection | DOAJ |
| description | Abstract Background N-terminal probrain natriuretic peptide (NT-pro-BNP) and BNP are well-known markers for the diagnosis and prognostic of heart failure. Until now, it was not clear whether BNP levels are influenced by events occurring within Obstructive sleep apnea–hypopnea syndrome (OSAHS) with continuous positive airway pressure (CPAP). Methods A thorough search in PubMed, EMBASE, Google Scholar, and Web of Science databases up to October 24, 2022, and a meta-analysis aimed to explore further accurate estimates of the effects of BNP on OSAHS after CPAP treatment to assess the strength of the evidence. Results The forest plot outcome indicated that CPAP therapy did not change the BNP level in patients with OSAHS, with a weighted mean difference (WMD) of -0.47 (95% CI: -1.67 to 2.62; P = 0.53] based on the random effect model because of high significant heterogeneity (I 2 = 80%) among the studies. Subgroup analysis also explored the changes in BNP levels in patients with OSAHS. Begg’s test (P = 0.835) and Egger’s test (P = 0.245) suggested significant negative publication bias. Conclusion Our meta-analysis suggests that CPAP therapy does not change the BNP level in patients with OSAHS; therefore, it is not accurate to use BNP level as an index to evaluate heart function in patients with OSAHS, but more related research should be conducted. |
| first_indexed | 2024-03-12T23:26:28Z |
| format | Article |
| id | doaj.art-b97affbf288a4b27bb2eee2cfc415953 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-03-12T23:26:28Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-b97affbf288a4b27bb2eee2cfc4159532023-07-16T11:08:20ZengBMCBMC Pulmonary Medicine1471-24662023-07-012311810.1186/s12890-023-02539-9Efficacy of continuous positive airway pressure on NT-pro-BNP in obstructive sleep apnea patients: a meta-analysisQinqin Wu0Xiaojun Ma1Yanyan Wang2Jianfeng Jin3Jia Li4Shuming Guo5Department of Pulmonary and Critical Care Medicine, Linfen Central HospitalDepartment of Pulmonary and Critical Care Medicine, Linfen Central HospitalDepartment of Pulmonary and Critical Care Medicine, Linfen Central HospitalDepartment of Pulmonary and Critical Care Medicine, Linfen Central HospitalDepartment of Pulmonary and Critical Care Medicine, Linfen Central HospitalLinfen Central HospitalAbstract Background N-terminal probrain natriuretic peptide (NT-pro-BNP) and BNP are well-known markers for the diagnosis and prognostic of heart failure. Until now, it was not clear whether BNP levels are influenced by events occurring within Obstructive sleep apnea–hypopnea syndrome (OSAHS) with continuous positive airway pressure (CPAP). Methods A thorough search in PubMed, EMBASE, Google Scholar, and Web of Science databases up to October 24, 2022, and a meta-analysis aimed to explore further accurate estimates of the effects of BNP on OSAHS after CPAP treatment to assess the strength of the evidence. Results The forest plot outcome indicated that CPAP therapy did not change the BNP level in patients with OSAHS, with a weighted mean difference (WMD) of -0.47 (95% CI: -1.67 to 2.62; P = 0.53] based on the random effect model because of high significant heterogeneity (I 2 = 80%) among the studies. Subgroup analysis also explored the changes in BNP levels in patients with OSAHS. Begg’s test (P = 0.835) and Egger’s test (P = 0.245) suggested significant negative publication bias. Conclusion Our meta-analysis suggests that CPAP therapy does not change the BNP level in patients with OSAHS; therefore, it is not accurate to use BNP level as an index to evaluate heart function in patients with OSAHS, but more related research should be conducted.https://doi.org/10.1186/s12890-023-02539-9N-terminal probrain natriuretic peptideObstructive sleep apnea–hypopnea syndromeContinuous positive airway pressureMeta-analysis |
| spellingShingle | Qinqin Wu Xiaojun Ma Yanyan Wang Jianfeng Jin Jia Li Shuming Guo Efficacy of continuous positive airway pressure on NT-pro-BNP in obstructive sleep apnea patients: a meta-analysis BMC Pulmonary Medicine N-terminal probrain natriuretic peptide Obstructive sleep apnea–hypopnea syndrome Continuous positive airway pressure Meta-analysis |
| title | Efficacy of continuous positive airway pressure on NT-pro-BNP in obstructive sleep apnea patients: a meta-analysis |
| title_full | Efficacy of continuous positive airway pressure on NT-pro-BNP in obstructive sleep apnea patients: a meta-analysis |
| title_fullStr | Efficacy of continuous positive airway pressure on NT-pro-BNP in obstructive sleep apnea patients: a meta-analysis |
| title_full_unstemmed | Efficacy of continuous positive airway pressure on NT-pro-BNP in obstructive sleep apnea patients: a meta-analysis |
| title_short | Efficacy of continuous positive airway pressure on NT-pro-BNP in obstructive sleep apnea patients: a meta-analysis |
| title_sort | efficacy of continuous positive airway pressure on nt pro bnp in obstructive sleep apnea patients a meta analysis |
| topic | N-terminal probrain natriuretic peptide Obstructive sleep apnea–hypopnea syndrome Continuous positive airway pressure Meta-analysis |
| url | https://doi.org/10.1186/s12890-023-02539-9 |
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