A novel rat model of Dravet syndrome recapitulates clinical hallmarks

A novel rat model of Dravet syndrome recapitulates clinical hallmarks

Dravet syndrome (DS) is a debilitating infantile epileptic encephalopathy characterized by seizures induced by high body temperature (hyperthermia), sudden unexpected death in epilepsy (SUDEP), cognitive impairment, and behavioral disturbances. The most common cause of DS is haploinsufficiency of th...

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Bibliographic Details
Main Authors: Miao Li, Lixin Yang, Weixin Qian, Saikat Ray, Zhonghua Lu, Tao Liu, Ying-Ying Zou, Robert K. Naumann, Hong Wang
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Neurobiology of Disease
Subjects:
Dravet syndrome
Rat
Scn1a
Epilepsy
Hyperthermia-induced seizure
EEG
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123002085

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