Screening studies of antimicrobial activity of pyrimidine derivative
Aim of the study was to screen the antimicrobial activity of pyrimidine derivative 3-[2-(1-naphthyl)-2-oxoethyl]-6-bromoquinazoline-4(3H)-oh with laboratory cipher VMA–13–06 in relation to pathogenic and opportunistic flora. Material and methods. Antimicrobial activity of VMA–13–06 was established i...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Siberian Branch Publishing House
2021-12-01
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| Series: | Сибирский научный медицинский журнал |
| Subjects: | |
| Online Access: | https://sibmed.elpub.ru/jour/article/view/698 |
| _version_ | 1797269552346693632 |
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| author | A. A. Tsibizova A. L. Yasenyavskaya A. A. Ozerov I. N. Tyurenkov O. A. Bashkina M. A. Samotrueva |
| author_facet | A. A. Tsibizova A. L. Yasenyavskaya A. A. Ozerov I. N. Tyurenkov O. A. Bashkina M. A. Samotrueva |
| author_sort | A. A. Tsibizova |
| collection | DOAJ |
| description | Aim of the study was to screen the antimicrobial activity of pyrimidine derivative 3-[2-(1-naphthyl)-2-oxoethyl]-6-bromoquinazoline-4(3H)-oh with laboratory cipher VMA–13–06 in relation to pathogenic and opportunistic flora. Material and methods. Antimicrobial activity of VMA–13–06 was established in vitro against strains of Staphylococcus aureus, Klebsiella pneumonia, Streptococcus pyogenes, Escherichia coli, Acinetobacter baumannii and Citrobacter freundii by the method of serial dilutions, by forming rows with different concentrations of the compound under study. Results. VMA–13–06 was found to exhibit high antibacterial activity against S. aureus, S. pyogenes, E. coli and K. pneumonia at concentrations of 128 and 64 μg/ml comparable to the activity of the comparison drug norfloxacin. At a concentration of 32 μg/ml, the studied derivative is highly active against S. aureus and S. pyogenes and shows average activity against E. coli and K. pneumonia. The compound VMA–13–06 in dilution from 16 to 4 μg/ml is moderately active against the above-mentioned microorganisms. At concentrations from 2 to 0.25 μg/ml, the pyrimidine derivative is inactive against S. aureus, S. pyogenes, E. coli and K. pneumonia, in all dilutions – against C. freundii and A. baumannii. Conclusions. The results of a screening study indicate a pronounced bactericidal effect of VMA–13–06 against S. aureus, S. pyogenes, E. coli и K. pneumonia comparable to the comparison drug norfloxacin. |
| first_indexed | 2024-03-08T14:33:16Z |
| format | Article |
| id | doaj.art-b97d7233193041558087487b9ecf37b2 |
| institution | Directory Open Access Journal |
| issn | 2410-2512 2410-2520 |
| language | Russian |
| last_indexed | 2024-04-25T01:50:11Z |
| publishDate | 2021-12-01 |
| publisher | Russian Academy of Sciences, Siberian Branch Publishing House |
| record_format | Article |
| series | Сибирский научный медицинский журнал |
| spelling | doaj.art-b97d7233193041558087487b9ecf37b22024-03-07T18:50:00ZrusRussian Academy of Sciences, Siberian Branch Publishing HouseСибирский научный медицинский журнал2410-25122410-25202021-12-01416566010.18699/SSMJ20210606394Screening studies of antimicrobial activity of pyrimidine derivativeA. A. Tsibizova0A. L. Yasenyavskaya1A. A. Ozerov2I. N. Tyurenkov3O. A. Bashkina4M. A. Samotrueva5Astrakhan State Medical University of Minzdrav of RussiaAstrakhan State Medical University of Minzdrav of RussiaVolgograd State Medical University of Minzdrav of RussiaVolgograd State Medical University of Minzdrav of RussiaAstrakhan State Medical University of Minzdrav of RussiaAstrakhan State Medical University of Minzdrav of RussiaAim of the study was to screen the antimicrobial activity of pyrimidine derivative 3-[2-(1-naphthyl)-2-oxoethyl]-6-bromoquinazoline-4(3H)-oh with laboratory cipher VMA–13–06 in relation to pathogenic and opportunistic flora. Material and methods. Antimicrobial activity of VMA–13–06 was established in vitro against strains of Staphylococcus aureus, Klebsiella pneumonia, Streptococcus pyogenes, Escherichia coli, Acinetobacter baumannii and Citrobacter freundii by the method of serial dilutions, by forming rows with different concentrations of the compound under study. Results. VMA–13–06 was found to exhibit high antibacterial activity against S. aureus, S. pyogenes, E. coli and K. pneumonia at concentrations of 128 and 64 μg/ml comparable to the activity of the comparison drug norfloxacin. At a concentration of 32 μg/ml, the studied derivative is highly active against S. aureus and S. pyogenes and shows average activity against E. coli and K. pneumonia. The compound VMA–13–06 in dilution from 16 to 4 μg/ml is moderately active against the above-mentioned microorganisms. At concentrations from 2 to 0.25 μg/ml, the pyrimidine derivative is inactive against S. aureus, S. pyogenes, E. coli and K. pneumonia, in all dilutions – against C. freundii and A. baumannii. Conclusions. The results of a screening study indicate a pronounced bactericidal effect of VMA–13–06 against S. aureus, S. pyogenes, E. coli и K. pneumonia comparable to the comparison drug norfloxacin.https://sibmed.elpub.ru/jour/article/view/698pyrimidine derivativesantimicrobial activitybactericidal effectbacteriostatic effect |
| spellingShingle | A. A. Tsibizova A. L. Yasenyavskaya A. A. Ozerov I. N. Tyurenkov O. A. Bashkina M. A. Samotrueva Screening studies of antimicrobial activity of pyrimidine derivative Сибирский научный медицинский журнал pyrimidine derivatives antimicrobial activity bactericidal effect bacteriostatic effect |
| title | Screening studies of antimicrobial activity of pyrimidine derivative |
| title_full | Screening studies of antimicrobial activity of pyrimidine derivative |
| title_fullStr | Screening studies of antimicrobial activity of pyrimidine derivative |
| title_full_unstemmed | Screening studies of antimicrobial activity of pyrimidine derivative |
| title_short | Screening studies of antimicrobial activity of pyrimidine derivative |
| title_sort | screening studies of antimicrobial activity of pyrimidine derivative |
| topic | pyrimidine derivatives antimicrobial activity bactericidal effect bacteriostatic effect |
| url | https://sibmed.elpub.ru/jour/article/view/698 |
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