Transporting Hydrogel via Chinese Acupuncture Needles for Lesion Positioning Therapy
Abstract Lesion positioning therapy optimizes medical treatment by directly targeting lesions. However, strong physical barriers greatly hinder its wide use. Here, the Chinese acupuncture needles (CA‐needles) with a screw‐thread structure at the tip (ST‐needle) and the hydrogel with the function of...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-06-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202200079 |
| _version_ | 1818544867279634432 |
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| author | Feng Lin Zhen Wang Lei Xiang Longxi Wu Yupu Liu Xiaobing Xi Lianfu Deng Wenguo Cui |
| author_facet | Feng Lin Zhen Wang Lei Xiang Longxi Wu Yupu Liu Xiaobing Xi Lianfu Deng Wenguo Cui |
| author_sort | Feng Lin |
| collection | DOAJ |
| description | Abstract Lesion positioning therapy optimizes medical treatment by directly targeting lesions. However, strong physical barriers greatly hinder its wide use. Here, the Chinese acupuncture needles (CA‐needles) with a screw‐thread structure at the tip (ST‐needle) and the hydrogel with the function of adhesive metal and loaded drug sustained‐release structure are designed, through the minimally invasive and precise positioning of lesions by ST‐needles, the dry‐wet conversion of hydrogel with absorbing fluids and swelling, and the rotation back of ST‐needles, the hydrogel is precisely positioned in the subchondral bone with physical barrier to achieve precise positioning therapy for lesions. In vitro experiments show that the ST‐needle penetrates the physical barrier of cartilage and enters the subchondral bone. Simultaneously, the hydrogel transfer efficiency of the ST‐needle (73.25%) is significantly higher than that of the CA‐needle (29.92%) due to the protective effect of the screw‐thread structure. In vivo experiments demonstrate that precise positioning in subchondral bone in osteoarthritis rats with ST‐needles effectively inhibits abnormal subchondral bone remodeling, alleviating the degeneration and degradation of cartilage. Therefore, ST‐needles achieve lesion positioning therapy through minimally invasive penetration of physical barriers, precisely positioning within lesions, and delivering hydrogel to release drugs. |
| first_indexed | 2024-12-11T22:54:03Z |
| format | Article |
| id | doaj.art-b97d9c484bc645499f01f31b38169e59 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-12-11T22:54:03Z |
| publishDate | 2022-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-b97d9c484bc645499f01f31b38169e592022-12-22T00:47:20ZengWileyAdvanced Science2198-38442022-06-01917n/an/a10.1002/advs.202200079Transporting Hydrogel via Chinese Acupuncture Needles for Lesion Positioning TherapyFeng Lin0Zhen Wang1Lei Xiang2Longxi Wu3Yupu Liu4Xiaobing Xi5Lianfu Deng6Wenguo Cui7Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine 197 Ruijin 2nd Road Shanghai 200025 P. R. ChinaDepartment of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine 197 Ruijin 2nd Road Shanghai 200025 P. R. ChinaDepartment of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine 197 Ruijin 2nd Road Shanghai 200025 P. R. ChinaDepartment of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine 197 Ruijin 2nd Road Shanghai 200025 P. R. ChinaDepartment of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine 197 Ruijin 2nd Road Shanghai 200025 P. R. ChinaDepartment of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine 197 Ruijin 2nd Road Shanghai 200025 P. R. ChinaDepartment of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine 197 Ruijin 2nd Road Shanghai 200025 P. R. ChinaDepartment of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine 197 Ruijin 2nd Road Shanghai 200025 P. R. ChinaAbstract Lesion positioning therapy optimizes medical treatment by directly targeting lesions. However, strong physical barriers greatly hinder its wide use. Here, the Chinese acupuncture needles (CA‐needles) with a screw‐thread structure at the tip (ST‐needle) and the hydrogel with the function of adhesive metal and loaded drug sustained‐release structure are designed, through the minimally invasive and precise positioning of lesions by ST‐needles, the dry‐wet conversion of hydrogel with absorbing fluids and swelling, and the rotation back of ST‐needles, the hydrogel is precisely positioned in the subchondral bone with physical barrier to achieve precise positioning therapy for lesions. In vitro experiments show that the ST‐needle penetrates the physical barrier of cartilage and enters the subchondral bone. Simultaneously, the hydrogel transfer efficiency of the ST‐needle (73.25%) is significantly higher than that of the CA‐needle (29.92%) due to the protective effect of the screw‐thread structure. In vivo experiments demonstrate that precise positioning in subchondral bone in osteoarthritis rats with ST‐needles effectively inhibits abnormal subchondral bone remodeling, alleviating the degeneration and degradation of cartilage. Therefore, ST‐needles achieve lesion positioning therapy through minimally invasive penetration of physical barriers, precisely positioning within lesions, and delivering hydrogel to release drugs.https://doi.org/10.1002/advs.202200079Chinese acupuncturehydrogellesion positioning therapymicroneedleosteoarthritis |
| spellingShingle | Feng Lin Zhen Wang Lei Xiang Longxi Wu Yupu Liu Xiaobing Xi Lianfu Deng Wenguo Cui Transporting Hydrogel via Chinese Acupuncture Needles for Lesion Positioning Therapy Advanced Science Chinese acupuncture hydrogel lesion positioning therapy microneedle osteoarthritis |
| title | Transporting Hydrogel via Chinese Acupuncture Needles for Lesion Positioning Therapy |
| title_full | Transporting Hydrogel via Chinese Acupuncture Needles for Lesion Positioning Therapy |
| title_fullStr | Transporting Hydrogel via Chinese Acupuncture Needles for Lesion Positioning Therapy |
| title_full_unstemmed | Transporting Hydrogel via Chinese Acupuncture Needles for Lesion Positioning Therapy |
| title_short | Transporting Hydrogel via Chinese Acupuncture Needles for Lesion Positioning Therapy |
| title_sort | transporting hydrogel via chinese acupuncture needles for lesion positioning therapy |
| topic | Chinese acupuncture hydrogel lesion positioning therapy microneedle osteoarthritis |
| url | https://doi.org/10.1002/advs.202200079 |
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