Factors associated with parametrial involvement in patients with stage IB1 cervical cancer: Who is suitable for less radical surgery?
ObjectiveTo detect the possible clinicopathologic factors associated with parametrial involvement in patients with stage IB1 cervical cancer and to identify a cohort of patients who may benefit from less radical surgery.MethodsWe retrospectively reviewed 120 patients who underwent radical hysterecto...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Obstetrics and Gynecology
2018-01-01
|
| Series: | Obstetrics & Gynecology Science |
| Subjects: | |
| Online Access: | http://ogscience.org/upload/pdf/ogs-61-88.pdf |
| _version_ | 1819074735354413056 |
|---|---|
| author | Seung-Ho Lee Kyoung-Joo Cho Mi-Hyang Ko Hyun-Yee Cho Kwang-Beom Lee Soyi Lim |
| author_facet | Seung-Ho Lee Kyoung-Joo Cho Mi-Hyang Ko Hyun-Yee Cho Kwang-Beom Lee Soyi Lim |
| author_sort | Seung-Ho Lee |
| collection | DOAJ |
| description | ObjectiveTo detect the possible clinicopathologic factors associated with parametrial involvement in patients with stage IB1 cervical cancer and to identify a cohort of patients who may benefit from less radical surgery.MethodsWe retrospectively reviewed 120 patients who underwent radical hysterectomy and pelvic lymphadenectomy as treatment for stage IB1 cervical cancer.ResultsOverall, 18 (15.0%) patients had parametrial tumor involvement. Tumor size larger than 2 cm, invasion depth greater than 1 cm, presence of lymphovascular space involvement (LVSI), corpus involvement, and positive lymph nodes were statistically associated with parametrial involvement. Multivariate analysis for other factors showed invasion depth >1 cm (P=0.029), and corpus involvement (P=0.022) were significantly associated with parametrial involvement. A subgroup with tumor size smaller than 2 cm showed no parametrial involvement, regardless of invasion depth or presence of LVSI.ConclusionTumor size smaller than 2 cm showed no parametrial involvement, regardless of invasion depth or presence of LVSI. Invasion depth >1 cm and corpus involvement were significantly associated with parametrial involvement in multivariate analysis. These finding may suggest that tumor size may a strong predictor of parametrial involvement in International Federation of Gynecology and Obstetrics stage IB1 cervical cancer, which can be used to select a subgroup population for less radical surgery. |
| first_indexed | 2024-12-21T18:14:14Z |
| format | Article |
| id | doaj.art-b97e57c4f5614acaa07aae78b89a4e16 |
| institution | Directory Open Access Journal |
| issn | 2287-8572 2287-8580 |
| language | English |
| last_indexed | 2024-12-21T18:14:14Z |
| publishDate | 2018-01-01 |
| publisher | Korean Society of Obstetrics and Gynecology |
| record_format | Article |
| series | Obstetrics & Gynecology Science |
| spelling | doaj.art-b97e57c4f5614acaa07aae78b89a4e162022-12-21T18:54:43ZengKorean Society of Obstetrics and GynecologyObstetrics & Gynecology Science2287-85722287-85802018-01-01611889410.5468/ogs.2018.61.1.88554Factors associated with parametrial involvement in patients with stage IB1 cervical cancer: Who is suitable for less radical surgery?Seung-Ho Lee0Kyoung-Joo Cho1Mi-Hyang Ko2Hyun-Yee Cho3Kwang-Beom Lee4Soyi Lim5Department of Obstetrics and Gynecology, Gil Medical Center, Gachon University of Medicine and Science, Incheon, .KoreaDepartment of Obstetrics and Gynecology, Gil Medical Center, Gachon University of Medicine and Science, Incheon, .KoreaDepartment of Obstetrics and Gynecology, Gil Medical Center, Gachon University of Medicine and Science, Incheon, .KoreaDepartment of Pathology, Gil Medical Center, Gachon University of Medicine and Science, Incheon, .KoreaDepartment of Obstetrics and Gynecology, Gil Medical Center, Gachon University of Medicine and Science, Incheon, .KoreaDepartment of Obstetrics and Gynecology, Gil Medical Center, Gachon University of Medicine and Science, Incheon, .KoreaObjectiveTo detect the possible clinicopathologic factors associated with parametrial involvement in patients with stage IB1 cervical cancer and to identify a cohort of patients who may benefit from less radical surgery.MethodsWe retrospectively reviewed 120 patients who underwent radical hysterectomy and pelvic lymphadenectomy as treatment for stage IB1 cervical cancer.ResultsOverall, 18 (15.0%) patients had parametrial tumor involvement. Tumor size larger than 2 cm, invasion depth greater than 1 cm, presence of lymphovascular space involvement (LVSI), corpus involvement, and positive lymph nodes were statistically associated with parametrial involvement. Multivariate analysis for other factors showed invasion depth >1 cm (P=0.029), and corpus involvement (P=0.022) were significantly associated with parametrial involvement. A subgroup with tumor size smaller than 2 cm showed no parametrial involvement, regardless of invasion depth or presence of LVSI.ConclusionTumor size smaller than 2 cm showed no parametrial involvement, regardless of invasion depth or presence of LVSI. Invasion depth >1 cm and corpus involvement were significantly associated with parametrial involvement in multivariate analysis. These finding may suggest that tumor size may a strong predictor of parametrial involvement in International Federation of Gynecology and Obstetrics stage IB1 cervical cancer, which can be used to select a subgroup population for less radical surgery.http://ogscience.org/upload/pdf/ogs-61-88.pdfuterine cervical neoplasmshysterectomy |
| spellingShingle | Seung-Ho Lee Kyoung-Joo Cho Mi-Hyang Ko Hyun-Yee Cho Kwang-Beom Lee Soyi Lim Factors associated with parametrial involvement in patients with stage IB1 cervical cancer: Who is suitable for less radical surgery? Obstetrics & Gynecology Science uterine cervical neoplasms hysterectomy |
| title | Factors associated with parametrial involvement in patients with stage IB1 cervical cancer: Who is suitable for less radical surgery? |
| title_full | Factors associated with parametrial involvement in patients with stage IB1 cervical cancer: Who is suitable for less radical surgery? |
| title_fullStr | Factors associated with parametrial involvement in patients with stage IB1 cervical cancer: Who is suitable for less radical surgery? |
| title_full_unstemmed | Factors associated with parametrial involvement in patients with stage IB1 cervical cancer: Who is suitable for less radical surgery? |
| title_short | Factors associated with parametrial involvement in patients with stage IB1 cervical cancer: Who is suitable for less radical surgery? |
| title_sort | factors associated with parametrial involvement in patients with stage ib1 cervical cancer who is suitable for less radical surgery |
| topic | uterine cervical neoplasms hysterectomy |
| url | http://ogscience.org/upload/pdf/ogs-61-88.pdf |
| work_keys_str_mv | AT seungholee factorsassociatedwithparametrialinvolvementinpatientswithstageib1cervicalcancerwhoissuitableforlessradicalsurgery AT kyoungjoocho factorsassociatedwithparametrialinvolvementinpatientswithstageib1cervicalcancerwhoissuitableforlessradicalsurgery AT mihyangko factorsassociatedwithparametrialinvolvementinpatientswithstageib1cervicalcancerwhoissuitableforlessradicalsurgery AT hyunyeecho factorsassociatedwithparametrialinvolvementinpatientswithstageib1cervicalcancerwhoissuitableforlessradicalsurgery AT kwangbeomlee factorsassociatedwithparametrialinvolvementinpatientswithstageib1cervicalcancerwhoissuitableforlessradicalsurgery AT soyilim factorsassociatedwithparametrialinvolvementinpatientswithstageib1cervicalcancerwhoissuitableforlessradicalsurgery |