Bioactive oat β-glucan reduces LDL cholesterol in Caucasians and non-Caucasians
<p>Abstract</p> <p>Background</p> <p>There is increasing global acceptance that viscous soluble fibers lower serum LDL cholesterol (LDL-C), but most evidence for this comes from studies in Caucasians. To see if oat β-glucan lowers LDL-C in Caucasians and non-Caucasians...
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BMC
2011-11-01
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Series: | Nutrition Journal |
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Online Access: | http://www.nutritionj.com/content/10/1/130 |
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author | Wolever Thomas MS Gibbs Alison L Brand-Miller Jennie Duncan Alison M Hart Valerie Lamarche Benoît Tosh Susan M Duss Ruedi |
author_facet | Wolever Thomas MS Gibbs Alison L Brand-Miller Jennie Duncan Alison M Hart Valerie Lamarche Benoît Tosh Susan M Duss Ruedi |
author_sort | Wolever Thomas MS |
collection | DOAJ |
description | <p>Abstract</p> <p>Background</p> <p>There is increasing global acceptance that viscous soluble fibers lower serum LDL cholesterol (LDL-C), but most evidence for this comes from studies in Caucasians. To see if oat β-glucan lowers LDL-C in Caucasians and non-Caucasians we conducted a post-hoc analysis of the results of a randomized, controlled, double-blind, multi-center clinical trial whose primary aim was to determine if molecular-weight (MW) influenced the LDL-C-lowering effect of oat β-glucan.</p> <p>Results</p> <p>Caucasian and non-Caucasian subjects with LDL-C-C ≥ 3.0 and ≤ 5.0 mmol/L (n = 786 screened, n = 400 ineligible, n = 19 refused, n = 367 randomized, n = 345 completed, n = 1 excluded for missing ethnicity) were randomly assigned to consume cereal containing wheat-fiber (Control, n = 74:13 Caucasian:non-Caucasian) or 3 g high-MW (3H, 2,250,000 g/mol, n = 67:19), 4 g medium-MW (4 M, 850,000 g/mol, n = 50:17), 3 g medium-MW (3M, 530,000 g/mol, n = 54:9) or 4 g low-MW (4 L, 210,000 g/mol, n = 51:12) oat β-glucan daily for 4 weeks. LDL-C after 4 weeks was influenced by baseline LDL-C (p < 0.001) and treatment (p = 0.003), but not ethnicity (p = 0.74). In all subjects, compared to control, 3 H, 4 M and 3 M reduced LDL-C significantly by 4.8 to 6.5%, but 4 L had no effect. Compared to control, the bioactive oat β-glucan treatments (3H, 4M and 3M) reduced LDL-C by a combined mean (95% CI) of 0.18 (0.06, 0.31) mmol/L (4.8%, n = 171, p = 0.004) in Caucasians, a value not significantly different from the 0.37 (0.09, 0.65) mmol/L (10.3%, n = 45, p = 0.008) reduction in non-Caucasians.</p> <p>Conclusion</p> <p>We conclude that oat β-glucan reduces LDL-C in both Caucasians and non-Caucasians; there was insufficient power to determine if the magnitude of LDL-C-lowering differed by ethnicity.</p> <p>Trial Registration</p> <p>ClinicalTrials.gov: <a href="http://www.clinicaltrials.gov/ct2/show/NCT00981981">NCT00981981</a></p> |
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issn | 1475-2891 |
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spelling | doaj.art-b97f05332fe2412ea0ac5e3b515297d72022-12-22T03:26:40ZengBMCNutrition Journal1475-28912011-11-0110113010.1186/1475-2891-10-130Bioactive oat β-glucan reduces LDL cholesterol in Caucasians and non-CaucasiansWolever Thomas MSGibbs Alison LBrand-Miller JennieDuncan Alison MHart ValerieLamarche BenoîtTosh Susan MDuss Ruedi<p>Abstract</p> <p>Background</p> <p>There is increasing global acceptance that viscous soluble fibers lower serum LDL cholesterol (LDL-C), but most evidence for this comes from studies in Caucasians. To see if oat β-glucan lowers LDL-C in Caucasians and non-Caucasians we conducted a post-hoc analysis of the results of a randomized, controlled, double-blind, multi-center clinical trial whose primary aim was to determine if molecular-weight (MW) influenced the LDL-C-lowering effect of oat β-glucan.</p> <p>Results</p> <p>Caucasian and non-Caucasian subjects with LDL-C-C ≥ 3.0 and ≤ 5.0 mmol/L (n = 786 screened, n = 400 ineligible, n = 19 refused, n = 367 randomized, n = 345 completed, n = 1 excluded for missing ethnicity) were randomly assigned to consume cereal containing wheat-fiber (Control, n = 74:13 Caucasian:non-Caucasian) or 3 g high-MW (3H, 2,250,000 g/mol, n = 67:19), 4 g medium-MW (4 M, 850,000 g/mol, n = 50:17), 3 g medium-MW (3M, 530,000 g/mol, n = 54:9) or 4 g low-MW (4 L, 210,000 g/mol, n = 51:12) oat β-glucan daily for 4 weeks. LDL-C after 4 weeks was influenced by baseline LDL-C (p < 0.001) and treatment (p = 0.003), but not ethnicity (p = 0.74). In all subjects, compared to control, 3 H, 4 M and 3 M reduced LDL-C significantly by 4.8 to 6.5%, but 4 L had no effect. Compared to control, the bioactive oat β-glucan treatments (3H, 4M and 3M) reduced LDL-C by a combined mean (95% CI) of 0.18 (0.06, 0.31) mmol/L (4.8%, n = 171, p = 0.004) in Caucasians, a value not significantly different from the 0.37 (0.09, 0.65) mmol/L (10.3%, n = 45, p = 0.008) reduction in non-Caucasians.</p> <p>Conclusion</p> <p>We conclude that oat β-glucan reduces LDL-C in both Caucasians and non-Caucasians; there was insufficient power to determine if the magnitude of LDL-C-lowering differed by ethnicity.</p> <p>Trial Registration</p> <p>ClinicalTrials.gov: <a href="http://www.clinicaltrials.gov/ct2/show/NCT00981981">NCT00981981</a></p>http://www.nutritionj.com/content/10/1/130Randomized clinical trialoatsbeta-glucanethnicitycholesterol |
spellingShingle | Wolever Thomas MS Gibbs Alison L Brand-Miller Jennie Duncan Alison M Hart Valerie Lamarche Benoît Tosh Susan M Duss Ruedi Bioactive oat β-glucan reduces LDL cholesterol in Caucasians and non-Caucasians Nutrition Journal Randomized clinical trial oats beta-glucan ethnicity cholesterol |
title | Bioactive oat β-glucan reduces LDL cholesterol in Caucasians and non-Caucasians |
title_full | Bioactive oat β-glucan reduces LDL cholesterol in Caucasians and non-Caucasians |
title_fullStr | Bioactive oat β-glucan reduces LDL cholesterol in Caucasians and non-Caucasians |
title_full_unstemmed | Bioactive oat β-glucan reduces LDL cholesterol in Caucasians and non-Caucasians |
title_short | Bioactive oat β-glucan reduces LDL cholesterol in Caucasians and non-Caucasians |
title_sort | bioactive oat β glucan reduces ldl cholesterol in caucasians and non caucasians |
topic | Randomized clinical trial oats beta-glucan ethnicity cholesterol |
url | http://www.nutritionj.com/content/10/1/130 |
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