Chemogenetic dissection of a prefrontal-hypothalamic circuit for socially subjective reward valuation in macaques
Abstract The value of one’s own reward is affected by the reward of others, serving as a source for envy. However, it is not known which neural circuits mediate such socially subjective value modulation. Here, we chemogenetically dissected the circuit from the medial prefrontal cortex (MPFC) to the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-40143-x |
| _version_ | 1797774106900299776 |
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| author | Atsushi Noritake Taihei Ninomiya Kenta Kobayashi Masaki Isoda |
| author_facet | Atsushi Noritake Taihei Ninomiya Kenta Kobayashi Masaki Isoda |
| author_sort | Atsushi Noritake |
| collection | DOAJ |
| description | Abstract The value of one’s own reward is affected by the reward of others, serving as a source for envy. However, it is not known which neural circuits mediate such socially subjective value modulation. Here, we chemogenetically dissected the circuit from the medial prefrontal cortex (MPFC) to the lateral hypothalamus (LH) while male macaques were presented with visual stimuli that concurrently signaled the prospects of one’s own and others’ rewards. We found that functional disconnection between the MPFC and LH rendered animals significantly less susceptible to others’ but not one’s own reward prospects. In parallel with this behavioral change, inter-areal coordination, as indexed by coherence and Granger causality, decreased primarily in the delta and theta bands. These findings demonstrate that the MPFC-to-LH circuit plays a crucial role in carrying information about upcoming other-rewards for subjective reward valuation in social contexts. |
| first_indexed | 2024-03-12T22:15:14Z |
| format | Article |
| id | doaj.art-b97f19a6a2dc42e2aca29cf1815dbe6b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-12T22:15:14Z |
| publishDate | 2023-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b97f19a6a2dc42e2aca29cf1815dbe6b2023-07-23T11:20:10ZengNature PortfolioNature Communications2041-17232023-07-011411910.1038/s41467-023-40143-xChemogenetic dissection of a prefrontal-hypothalamic circuit for socially subjective reward valuation in macaquesAtsushi Noritake0Taihei Ninomiya1Kenta Kobayashi2Masaki Isoda3Division of Behavioral Development, Department of System Neuroscience, National Institute for Physiological Sciences, National Institutes of Natural SciencesDivision of Behavioral Development, Department of System Neuroscience, National Institute for Physiological Sciences, National Institutes of Natural SciencesDepartment of Physiological Sciences, School of Life Science, The Graduate University for Advanced Studies (SOKENDAI)Division of Behavioral Development, Department of System Neuroscience, National Institute for Physiological Sciences, National Institutes of Natural SciencesAbstract The value of one’s own reward is affected by the reward of others, serving as a source for envy. However, it is not known which neural circuits mediate such socially subjective value modulation. Here, we chemogenetically dissected the circuit from the medial prefrontal cortex (MPFC) to the lateral hypothalamus (LH) while male macaques were presented with visual stimuli that concurrently signaled the prospects of one’s own and others’ rewards. We found that functional disconnection between the MPFC and LH rendered animals significantly less susceptible to others’ but not one’s own reward prospects. In parallel with this behavioral change, inter-areal coordination, as indexed by coherence and Granger causality, decreased primarily in the delta and theta bands. These findings demonstrate that the MPFC-to-LH circuit plays a crucial role in carrying information about upcoming other-rewards for subjective reward valuation in social contexts.https://doi.org/10.1038/s41467-023-40143-x |
| spellingShingle | Atsushi Noritake Taihei Ninomiya Kenta Kobayashi Masaki Isoda Chemogenetic dissection of a prefrontal-hypothalamic circuit for socially subjective reward valuation in macaques Nature Communications |
| title | Chemogenetic dissection of a prefrontal-hypothalamic circuit for socially subjective reward valuation in macaques |
| title_full | Chemogenetic dissection of a prefrontal-hypothalamic circuit for socially subjective reward valuation in macaques |
| title_fullStr | Chemogenetic dissection of a prefrontal-hypothalamic circuit for socially subjective reward valuation in macaques |
| title_full_unstemmed | Chemogenetic dissection of a prefrontal-hypothalamic circuit for socially subjective reward valuation in macaques |
| title_short | Chemogenetic dissection of a prefrontal-hypothalamic circuit for socially subjective reward valuation in macaques |
| title_sort | chemogenetic dissection of a prefrontal hypothalamic circuit for socially subjective reward valuation in macaques |
| url | https://doi.org/10.1038/s41467-023-40143-x |
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