Vanillin: A Promising Biosourced Building Block for the Preparation of Various Heterocycles
The preparation of heterocyclic compounds often involves the use of petroleum-based or non-renewable sources. Considering the actual societal and environmental awareness towards sustainable chemistry, new and green sources of organic carbon are sought. In this regard, vanillin is a molecular buildin...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2022.949355/full |
| _version_ | 1818469493819572224 |
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| author | David Gendron |
| author_facet | David Gendron |
| author_sort | David Gendron |
| collection | DOAJ |
| description | The preparation of heterocyclic compounds often involves the use of petroleum-based or non-renewable sources. Considering the actual societal and environmental awareness towards sustainable chemistry, new and green sources of organic carbon are sought. In this regard, vanillin is a molecular building block that can be obtained from the depolymerization of lignin. Due to its different functional groups (hydroxyl, aldehyde, and methoxy) vanillin can undergo a variety of reactions leading to various heterocycles such as pyrimidines, quinoxalines, imidazoles or thiazoles to name a few. This mini-review will focus on the preparation of accessible heterocycles building blocks from the vanillin moiety in regard to the medicinal, pharmaceutical, and material fields. |
| first_indexed | 2024-04-13T21:24:28Z |
| format | Article |
| id | doaj.art-b97f25452e97437ebcb7623acac8a437 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-04-13T21:24:28Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-b97f25452e97437ebcb7623acac8a4372022-12-22T02:29:22ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462022-07-011010.3389/fchem.2022.949355949355Vanillin: A Promising Biosourced Building Block for the Preparation of Various HeterocyclesDavid GendronThe preparation of heterocyclic compounds often involves the use of petroleum-based or non-renewable sources. Considering the actual societal and environmental awareness towards sustainable chemistry, new and green sources of organic carbon are sought. In this regard, vanillin is a molecular building block that can be obtained from the depolymerization of lignin. Due to its different functional groups (hydroxyl, aldehyde, and methoxy) vanillin can undergo a variety of reactions leading to various heterocycles such as pyrimidines, quinoxalines, imidazoles or thiazoles to name a few. This mini-review will focus on the preparation of accessible heterocycles building blocks from the vanillin moiety in regard to the medicinal, pharmaceutical, and material fields.https://www.frontiersin.org/articles/10.3389/fchem.2022.949355/fullvanillinbiosourcedheterocyclesgreen chemistrysynthesisaromatic ring |
| spellingShingle | David Gendron Vanillin: A Promising Biosourced Building Block for the Preparation of Various Heterocycles Frontiers in Chemistry vanillin biosourced heterocycles green chemistry synthesis aromatic ring |
| title | Vanillin: A Promising Biosourced Building Block for the Preparation of Various Heterocycles |
| title_full | Vanillin: A Promising Biosourced Building Block for the Preparation of Various Heterocycles |
| title_fullStr | Vanillin: A Promising Biosourced Building Block for the Preparation of Various Heterocycles |
| title_full_unstemmed | Vanillin: A Promising Biosourced Building Block for the Preparation of Various Heterocycles |
| title_short | Vanillin: A Promising Biosourced Building Block for the Preparation of Various Heterocycles |
| title_sort | vanillin a promising biosourced building block for the preparation of various heterocycles |
| topic | vanillin biosourced heterocycles green chemistry synthesis aromatic ring |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2022.949355/full |
| work_keys_str_mv | AT davidgendron vanillinapromisingbiosourcedbuildingblockforthepreparationofvariousheterocycles |