Evaluation of Serum S100A8/S100A9 Levels in Patients with Autoimmune Thyroid Diseases
Background: The correlation of S100A8/S100A9 with various inflammatory conditions, including autoimmune diseases have been reported. There is no study investigating the levels of S100A8/S100A9 in autoimmune thyroid diseases (AITD) Aims: We aimed to evaluate the level of serum S100A8/S100A9 in AIT...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2016-10-01
|
| Series: | Balkan Medical Journal |
| Subjects: | |
| Online Access: | http://balkanmedicaljournal.org/text.php?lang=en&id=12 |
| _version_ | 1797922618404241408 |
|---|---|
| author | Hakan Korkmaz Suzan Tabur Esen Savaş Mesut Özkaya Nurten Aksoy Şefika Nur Aksoy Ersin Akarsu |
| author_facet | Hakan Korkmaz Suzan Tabur Esen Savaş Mesut Özkaya Nurten Aksoy Şefika Nur Aksoy Ersin Akarsu |
| author_sort | Hakan Korkmaz |
| collection | DOAJ |
| description | Background: The correlation of S100A8/S100A9 with various inflammatory conditions, including autoimmune diseases have been reported. There is no study investigating the levels of S100A8/S100A9 in autoimmune thyroid diseases (AITD)
Aims: We aimed to evaluate the level of serum S100A8/S100A9 in AITD.
Study Design: Case control study.
Methods: Fifty patients with AITD (25 Hashimoto’s thyroiditis (HT) and 25 Graves’ disease (GD)) were included in the study. Twenty seven healthy subjects participated as a control group. Blood samples were obtained in the 3 months after the initiation of medical treatment. Serum levels of total antioxidant status (TAS), total oxidative status (TOS), total free sulfhydryl (SH), lipid hydroperoxide (LOOH) and S100A8/S100A9 were analyzed.
Results: The patients with AITD had significantly higher S100A8/S100A9, OSI, LOOH and TOS levels than the healthy control group. There was no significant difference between GD and HT patients in terms of S100A8/S100A9, TOS and OSI levels. S100A8/S100A9 level was positively correlated with LOOH, TOS and OSI levels but negatively correlated with –SH level in the patients with AITD.
Conclusion: Serum S100A8/S100A9 levels were increased in patients with AITD and positively correlated with LOOH, TOS and OSI whereas negatively correlated with SH. |
| first_indexed | 2024-04-10T14:35:18Z |
| format | Article |
| id | doaj.art-b97f8df912ac4ef5a71ab0174df2f8f3 |
| institution | Directory Open Access Journal |
| issn | 2146-3123 2146-3131 |
| language | English |
| last_indexed | 2024-04-10T14:35:18Z |
| publishDate | 2016-10-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Balkan Medical Journal |
| spelling | doaj.art-b97f8df912ac4ef5a71ab0174df2f8f32023-02-15T16:08:39ZengGalenos Publishing HouseBalkan Medical Journal2146-31232146-31312016-10-0133554755110.5152/balkanmedj.2016.15881Evaluation of Serum S100A8/S100A9 Levels in Patients with Autoimmune Thyroid DiseasesHakan Korkmaz0Suzan Tabur1Esen Savaş2Mesut Özkaya3Nurten Aksoy4Şefika Nur Aksoy5Ersin Akarsu6Department of Endocrinology and Metabolic Disease, Edirne State Hospital, Edirne, TurkeyDivision of Endocrinology, Department of Internal Medicine, Gaziantep University School of Medicine, Gaziantep, TurkeyDepartment of Internal Medicine, Gaziantep University School of Medicine, Gaziantep, TurkeyDivision of Endocrinology, Department of Internal Medicine, Gaziantep University School of Medicine, Gaziantep, TurkeyDepartment of Clinical Biochemistry, Harran University School of Medicine, Şanlıurfa, TurkeyDepartment of Clinical Biochemistry, Gaziantep University School of Medicine, Gaziantep, TurkeyDivision of Endocrinology, Department of Internal Medicine, Gaziantep University School of Medicine, Gaziantep, TurkeyBackground: The correlation of S100A8/S100A9 with various inflammatory conditions, including autoimmune diseases have been reported. There is no study investigating the levels of S100A8/S100A9 in autoimmune thyroid diseases (AITD) Aims: We aimed to evaluate the level of serum S100A8/S100A9 in AITD. Study Design: Case control study. Methods: Fifty patients with AITD (25 Hashimoto’s thyroiditis (HT) and 25 Graves’ disease (GD)) were included in the study. Twenty seven healthy subjects participated as a control group. Blood samples were obtained in the 3 months after the initiation of medical treatment. Serum levels of total antioxidant status (TAS), total oxidative status (TOS), total free sulfhydryl (SH), lipid hydroperoxide (LOOH) and S100A8/S100A9 were analyzed. Results: The patients with AITD had significantly higher S100A8/S100A9, OSI, LOOH and TOS levels than the healthy control group. There was no significant difference between GD and HT patients in terms of S100A8/S100A9, TOS and OSI levels. S100A8/S100A9 level was positively correlated with LOOH, TOS and OSI levels but negatively correlated with –SH level in the patients with AITD. Conclusion: Serum S100A8/S100A9 levels were increased in patients with AITD and positively correlated with LOOH, TOS and OSI whereas negatively correlated with SH.http://balkanmedicaljournal.org/text.php?lang=en&id=12Autoimmune thyroid diseaseoxidative statusS100A8/S100A9 |
| spellingShingle | Hakan Korkmaz Suzan Tabur Esen Savaş Mesut Özkaya Nurten Aksoy Şefika Nur Aksoy Ersin Akarsu Evaluation of Serum S100A8/S100A9 Levels in Patients with Autoimmune Thyroid Diseases Balkan Medical Journal Autoimmune thyroid disease oxidative status S100A8/S100A9 |
| title | Evaluation of Serum S100A8/S100A9 Levels in Patients with Autoimmune Thyroid Diseases |
| title_full | Evaluation of Serum S100A8/S100A9 Levels in Patients with Autoimmune Thyroid Diseases |
| title_fullStr | Evaluation of Serum S100A8/S100A9 Levels in Patients with Autoimmune Thyroid Diseases |
| title_full_unstemmed | Evaluation of Serum S100A8/S100A9 Levels in Patients with Autoimmune Thyroid Diseases |
| title_short | Evaluation of Serum S100A8/S100A9 Levels in Patients with Autoimmune Thyroid Diseases |
| title_sort | evaluation of serum s100a8 s100a9 levels in patients with autoimmune thyroid diseases |
| topic | Autoimmune thyroid disease oxidative status S100A8/S100A9 |
| url | http://balkanmedicaljournal.org/text.php?lang=en&id=12 |
| work_keys_str_mv | AT hakankorkmaz evaluationofserums100a8s100a9levelsinpatientswithautoimmunethyroiddiseases AT suzantabur evaluationofserums100a8s100a9levelsinpatientswithautoimmunethyroiddiseases AT esensavas evaluationofserums100a8s100a9levelsinpatientswithautoimmunethyroiddiseases AT mesutozkaya evaluationofserums100a8s100a9levelsinpatientswithautoimmunethyroiddiseases AT nurtenaksoy evaluationofserums100a8s100a9levelsinpatientswithautoimmunethyroiddiseases AT sefikanuraksoy evaluationofserums100a8s100a9levelsinpatientswithautoimmunethyroiddiseases AT ersinakarsu evaluationofserums100a8s100a9levelsinpatientswithautoimmunethyroiddiseases |