Factors Determining the Morphology of Peripapillary Retinoschisis
Reimi Nishijima,1,2 Shumpei Ogawa,1 Euido Nishijima,1 Yoshinori Itoh,1 Keiji Yoshikawa,1,3 Tadashi Nakano1 1Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan; 2Department of Ophthalmology, The Jikei University Katsushika Medical Center, Tokyo, Japan; 3Yoshikawa Eye C...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-03-01
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| Series: | Clinical Ophthalmology |
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| Online Access: | https://www.dovepress.com/factors-determining-the-morphology-of-peripapillary-retinoschisis-peer-reviewed-article-OPTH |
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| author | Nishijima R Ogawa S Nishijima E Itoh Y Yoshikawa K Nakano T |
| author_facet | Nishijima R Ogawa S Nishijima E Itoh Y Yoshikawa K Nakano T |
| author_sort | Nishijima R |
| collection | DOAJ |
| description | Reimi Nishijima,1,2 Shumpei Ogawa,1 Euido Nishijima,1 Yoshinori Itoh,1 Keiji Yoshikawa,1,3 Tadashi Nakano1 1Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan; 2Department of Ophthalmology, The Jikei University Katsushika Medical Center, Tokyo, Japan; 3Yoshikawa Eye Clinic, Machida-city, Tokyo, JapanCorrespondence: Shumpei OgawaDepartment of Ophthalmology, The Jikei University School of Medicine, 3-19-18 Nishi-Shinbashi, Minato-ku, Tokyo, 105-8471, JapanTel +813 3433 1111Fax +813 3433 1936Email shmp0722@gmail.comPurpose: We conducted cross-sectional examinations to determine the frequency of peripapillary retinoschisis (PRS) in eyes with glaucoma and suspected glaucoma and analyzed the pathogenesis of PRS by using spectral-domain optical coherence tomography (SD-OCT).Patients and Methods: In 1516 cases involving glaucoma and suspected glaucoma, we retrospectively reviewed the disc and macular volume scans obtained by SD-OCT and categorized PRS into two groups based on whether the retinoschisis was closer to the optic nerve over the Bruch’s membrane opening (BMO) (ahead group) or did not go past the BMO (behind group) and then compared the characteristics between both groups.Results: The total frequency of PRS was 1.49% (20/1342 eyes) in primary open-angle glaucoma (POAG) eyes and 0.59% (10/1687 eyes) in glaucoma suspects. In the behind group, PRS was mostly detected in the inner layers of the retina (retinal nerve fiber layer: 30.9%, ganglion cell layer: 21.8%, inner plexiform layer: 7.3%). However, in the ahead group, PRS was detected in the outer layers (inner nuclear layer: 10%, outer plexiform layer: 20%, outer nuclear layer: 50%). In addition, the eyes in the ahead group had significantly greater axial lengths and significantly smaller spherical equivalent values. These two differences suggest that the pulling force of the vitreous traction may play an important role in PRS only in the behind group and that the scleral stretching force may play a role in the development of PRS in the ahead group.Conclusion: The frequency of PRS in patients with POAG is higher than that in patients with suspected glaucoma. Both forms of PRS are affected by posterior vitreous detachment and axial length elongation. Careful follow-up is required to assess the development of PRS in glaucoma suspects. The pathogenesis of PRS has been elucidated to some degree by classifying the morphological condition of the PRS and BMO.Keywords: peripapillary retinoschisis, optical coherent tomography, glaucoma, myopia |
| first_indexed | 2024-12-19T04:30:33Z |
| format | Article |
| id | doaj.art-b981cc8da14245e09c45d572b31d9bbc |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-12-19T04:30:33Z |
| publishDate | 2021-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-b981cc8da14245e09c45d572b31d9bbc2022-12-21T20:35:53ZengDove Medical PressClinical Ophthalmology1177-54832021-03-01Volume 151293130063436Factors Determining the Morphology of Peripapillary RetinoschisisNishijima ROgawa SNishijima EItoh YYoshikawa KNakano TReimi Nishijima,1,2 Shumpei Ogawa,1 Euido Nishijima,1 Yoshinori Itoh,1 Keiji Yoshikawa,1,3 Tadashi Nakano1 1Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan; 2Department of Ophthalmology, The Jikei University Katsushika Medical Center, Tokyo, Japan; 3Yoshikawa Eye Clinic, Machida-city, Tokyo, JapanCorrespondence: Shumpei OgawaDepartment of Ophthalmology, The Jikei University School of Medicine, 3-19-18 Nishi-Shinbashi, Minato-ku, Tokyo, 105-8471, JapanTel +813 3433 1111Fax +813 3433 1936Email shmp0722@gmail.comPurpose: We conducted cross-sectional examinations to determine the frequency of peripapillary retinoschisis (PRS) in eyes with glaucoma and suspected glaucoma and analyzed the pathogenesis of PRS by using spectral-domain optical coherence tomography (SD-OCT).Patients and Methods: In 1516 cases involving glaucoma and suspected glaucoma, we retrospectively reviewed the disc and macular volume scans obtained by SD-OCT and categorized PRS into two groups based on whether the retinoschisis was closer to the optic nerve over the Bruch’s membrane opening (BMO) (ahead group) or did not go past the BMO (behind group) and then compared the characteristics between both groups.Results: The total frequency of PRS was 1.49% (20/1342 eyes) in primary open-angle glaucoma (POAG) eyes and 0.59% (10/1687 eyes) in glaucoma suspects. In the behind group, PRS was mostly detected in the inner layers of the retina (retinal nerve fiber layer: 30.9%, ganglion cell layer: 21.8%, inner plexiform layer: 7.3%). However, in the ahead group, PRS was detected in the outer layers (inner nuclear layer: 10%, outer plexiform layer: 20%, outer nuclear layer: 50%). In addition, the eyes in the ahead group had significantly greater axial lengths and significantly smaller spherical equivalent values. These two differences suggest that the pulling force of the vitreous traction may play an important role in PRS only in the behind group and that the scleral stretching force may play a role in the development of PRS in the ahead group.Conclusion: The frequency of PRS in patients with POAG is higher than that in patients with suspected glaucoma. Both forms of PRS are affected by posterior vitreous detachment and axial length elongation. Careful follow-up is required to assess the development of PRS in glaucoma suspects. The pathogenesis of PRS has been elucidated to some degree by classifying the morphological condition of the PRS and BMO.Keywords: peripapillary retinoschisis, optical coherent tomography, glaucoma, myopiahttps://www.dovepress.com/factors-determining-the-morphology-of-peripapillary-retinoschisis-peer-reviewed-article-OPTHperipapillary retinoschisisoptical coherent tomographyglaucomamyopia |
| spellingShingle | Nishijima R Ogawa S Nishijima E Itoh Y Yoshikawa K Nakano T Factors Determining the Morphology of Peripapillary Retinoschisis Clinical Ophthalmology peripapillary retinoschisis optical coherent tomography glaucoma myopia |
| title | Factors Determining the Morphology of Peripapillary Retinoschisis |
| title_full | Factors Determining the Morphology of Peripapillary Retinoschisis |
| title_fullStr | Factors Determining the Morphology of Peripapillary Retinoschisis |
| title_full_unstemmed | Factors Determining the Morphology of Peripapillary Retinoschisis |
| title_short | Factors Determining the Morphology of Peripapillary Retinoschisis |
| title_sort | factors determining the morphology of peripapillary retinoschisis |
| topic | peripapillary retinoschisis optical coherent tomography glaucoma myopia |
| url | https://www.dovepress.com/factors-determining-the-morphology-of-peripapillary-retinoschisis-peer-reviewed-article-OPTH |
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