Dysgerminoma in a female with turner syndrome and Y chromosome material: A case-based review of literature
We report a 17-year-old girl evaluated for primary amenorrhea. Cytogenetic analysis of the peripheral blood lymphocytes revealed normal autosomes with 46X inv (Y) confirming the diagnosis of Turner′s syndrome with Y cell line. Treatment was initiated with conjugated estrogen while recommending bilat...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2012-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2012;volume=16;issue=3;spage=436;epage=440;aulast=Kota |
| _version_ | 1817987712274137088 |
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| author | Sunil Kumar Kota Kotni Gayatri Jaya Prakash Pani Siva Krishna Kota Lalit Kumar Meher Kirtikumar D Modi |
| author_facet | Sunil Kumar Kota Kotni Gayatri Jaya Prakash Pani Siva Krishna Kota Lalit Kumar Meher Kirtikumar D Modi |
| author_sort | Sunil Kumar Kota |
| collection | DOAJ |
| description | We report a 17-year-old girl evaluated for primary amenorrhea. Cytogenetic analysis of the peripheral blood lymphocytes revealed normal autosomes with 46X inv (Y) confirming the diagnosis of Turner′s syndrome with Y cell line. Treatment was initiated with conjugated estrogen while recommending bilateral prophylactic oophorectomy to the patient. One year later the patient presented with abdominal mass, biopsy of the specimen following resection confirmed dysgerminoma originating from right ovary with no invasion or metastasis. The literature is reviewed with regard to the various pathogenetic mechanisms proposed for the development of germ cell tumors in ovary, the cytogenetic findings and recommendations to handle such scenario. |
| first_indexed | 2024-04-14T00:25:00Z |
| format | Article |
| id | doaj.art-b982d70d9b24418389a54d310431d0f2 |
| institution | Directory Open Access Journal |
| issn | 2230-8210 2230-9500 |
| language | English |
| last_indexed | 2024-04-14T00:25:00Z |
| publishDate | 2012-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-b982d70d9b24418389a54d310431d0f22022-12-22T02:22:47ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102230-95002012-01-0116343644010.4103/2230-8210.95706Dysgerminoma in a female with turner syndrome and Y chromosome material: A case-based review of literatureSunil Kumar KotaKotni GayatriJaya Prakash PaniSiva Krishna KotaLalit Kumar MeherKirtikumar D ModiWe report a 17-year-old girl evaluated for primary amenorrhea. Cytogenetic analysis of the peripheral blood lymphocytes revealed normal autosomes with 46X inv (Y) confirming the diagnosis of Turner′s syndrome with Y cell line. Treatment was initiated with conjugated estrogen while recommending bilateral prophylactic oophorectomy to the patient. One year later the patient presented with abdominal mass, biopsy of the specimen following resection confirmed dysgerminoma originating from right ovary with no invasion or metastasis. The literature is reviewed with regard to the various pathogenetic mechanisms proposed for the development of germ cell tumors in ovary, the cytogenetic findings and recommendations to handle such scenario.http://www.ijem.in/article.asp?issn=2230-8210;year=2012;volume=16;issue=3;spage=436;epage=440;aulast=KotaDysgermonomagonadal dysgenesisgonadoblastomamosaicismTurner′s syndromeY cell line |
| spellingShingle | Sunil Kumar Kota Kotni Gayatri Jaya Prakash Pani Siva Krishna Kota Lalit Kumar Meher Kirtikumar D Modi Dysgerminoma in a female with turner syndrome and Y chromosome material: A case-based review of literature Indian Journal of Endocrinology and Metabolism Dysgermonoma gonadal dysgenesis gonadoblastoma mosaicism Turner′s syndrome Y cell line |
| title | Dysgerminoma in a female with turner syndrome and Y chromosome material: A case-based review of literature |
| title_full | Dysgerminoma in a female with turner syndrome and Y chromosome material: A case-based review of literature |
| title_fullStr | Dysgerminoma in a female with turner syndrome and Y chromosome material: A case-based review of literature |
| title_full_unstemmed | Dysgerminoma in a female with turner syndrome and Y chromosome material: A case-based review of literature |
| title_short | Dysgerminoma in a female with turner syndrome and Y chromosome material: A case-based review of literature |
| title_sort | dysgerminoma in a female with turner syndrome and y chromosome material a case based review of literature |
| topic | Dysgermonoma gonadal dysgenesis gonadoblastoma mosaicism Turner′s syndrome Y cell line |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2012;volume=16;issue=3;spage=436;epage=440;aulast=Kota |
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