Dietary Antioxidants and Lung Cancer Risk in Smokers and Non-Smokers
Smoking is considered a major risk factor in the development of lung diseases worldwide. Active smoking and secondhand (passive) smoke (SHS) are related to lung cancer (LC) risk. Oxidative stress (OS) and/or lipid peroxidation (LP) induced by cigarette smoke (CS) are found to be involved in the path...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Healthcare |
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| Online Access: | https://www.mdpi.com/2227-9032/10/12/2501 |
| _version_ | 1797457501203988480 |
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| author | Naser A. Alsharairi |
| author_facet | Naser A. Alsharairi |
| author_sort | Naser A. Alsharairi |
| collection | DOAJ |
| description | Smoking is considered a major risk factor in the development of lung diseases worldwide. Active smoking and secondhand (passive) smoke (SHS) are related to lung cancer (LC) risk. Oxidative stress (OS) and/or lipid peroxidation (LP) induced by cigarette smoke (CS) are found to be involved in the pathogenesis of LC. Meta-analyses and other case-control/prospective cohort studies are inconclusive and have yielded inconsistent results concerning the protective role of dietary vitamins C and E, retinol, and iron intake against LC risk in smokers and/or non-smokers. Furthermore, the role of vitamins and minerals as antioxidants with the potential in protecting LC cells against CS-induced OS in smokers and non-smokers has not been fully elucidated. Thus, this review aims to summarize the available evidence reporting the relationships between dietary antioxidant intake and LC risk in smokers and non-smokers that may be used to provide suggestions for future research. |
| first_indexed | 2024-03-09T16:23:00Z |
| format | Article |
| id | doaj.art-b98328c721f64dd1b272c95cc4cbe70e |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-09T16:23:00Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-b98328c721f64dd1b272c95cc4cbe70e2023-11-24T15:11:11ZengMDPI AGHealthcare2227-90322022-12-011012250110.3390/healthcare10122501Dietary Antioxidants and Lung Cancer Risk in Smokers and Non-SmokersNaser A. Alsharairi0Heart, Mind & Body Research Group, Griffith University, Gold Coast, QLD 4222, AustraliaSmoking is considered a major risk factor in the development of lung diseases worldwide. Active smoking and secondhand (passive) smoke (SHS) are related to lung cancer (LC) risk. Oxidative stress (OS) and/or lipid peroxidation (LP) induced by cigarette smoke (CS) are found to be involved in the pathogenesis of LC. Meta-analyses and other case-control/prospective cohort studies are inconclusive and have yielded inconsistent results concerning the protective role of dietary vitamins C and E, retinol, and iron intake against LC risk in smokers and/or non-smokers. Furthermore, the role of vitamins and minerals as antioxidants with the potential in protecting LC cells against CS-induced OS in smokers and non-smokers has not been fully elucidated. Thus, this review aims to summarize the available evidence reporting the relationships between dietary antioxidant intake and LC risk in smokers and non-smokers that may be used to provide suggestions for future research.https://www.mdpi.com/2227-9032/10/12/2501dietary antioxidantsvitaminsmineralslung canceroxidative stresslipid peroxidation |
| spellingShingle | Naser A. Alsharairi Dietary Antioxidants and Lung Cancer Risk in Smokers and Non-Smokers Healthcare dietary antioxidants vitamins minerals lung cancer oxidative stress lipid peroxidation |
| title | Dietary Antioxidants and Lung Cancer Risk in Smokers and Non-Smokers |
| title_full | Dietary Antioxidants and Lung Cancer Risk in Smokers and Non-Smokers |
| title_fullStr | Dietary Antioxidants and Lung Cancer Risk in Smokers and Non-Smokers |
| title_full_unstemmed | Dietary Antioxidants and Lung Cancer Risk in Smokers and Non-Smokers |
| title_short | Dietary Antioxidants and Lung Cancer Risk in Smokers and Non-Smokers |
| title_sort | dietary antioxidants and lung cancer risk in smokers and non smokers |
| topic | dietary antioxidants vitamins minerals lung cancer oxidative stress lipid peroxidation |
| url | https://www.mdpi.com/2227-9032/10/12/2501 |
| work_keys_str_mv | AT naseraalsharairi dietaryantioxidantsandlungcancerriskinsmokersandnonsmokers |