3D Printed Individualized Frontal Neo-Ostium Implant in Endoscopic Sinus Surgery – a Proof of Concept Study
3D-printing paves the way for personalized drug therapy via implants individualized for the patient specific anatomy in chronic paranasal sinus diseases. This study brings together the workflow of modeling, manufacturing, and sterilization of 3D-printed individualized frontal neo-ostium implants (FO...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2021-10-01
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| Series: | Current Directions in Biomedical Engineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/cdbme-2021-2103 |
| _version_ | 1817981811279527936 |
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| author | Gao Ziwen Matin Farnaz Wei Chunjiang Lenarz Thomas Weber Constantin John Samuel Scheper Verena |
| author_facet | Gao Ziwen Matin Farnaz Wei Chunjiang Lenarz Thomas Weber Constantin John Samuel Scheper Verena |
| author_sort | Gao Ziwen |
| collection | DOAJ |
| description | 3D-printing paves the way for personalized drug therapy via implants individualized for the patient specific anatomy in chronic paranasal sinus diseases. This study brings together the workflow of modeling, manufacturing, and sterilization of 3D-printed individualized frontal neo-ostium implants (FOI) for optimization of Endoscopic Sinus Surgery (ESS) and validates the implantability of the printed devices. The study sample consisted of six adult human cadavers. Digital volume tomography (DVT) images were taken before and after ESS. The FOI models were based on the post-ESS anatomy. The area to be implanted was analysed in the preand post-ESS DVT images for volume and surface area. A specialized surgeon in rhinology judged the implantability of the 3D-printed FOI. The mean values of volume and surface area tended to be larger in the post-operation situs than in preoperation DVT images and we are therefore not yet convinced that pre-operation images will reflect the correct anatomy for the personalization of the FOI. The workflow of manufacturing and implantation of individualized 3D-printed sterile FOI is established but future studies are needed for further improvement. |
| first_indexed | 2024-04-13T23:12:11Z |
| format | Article |
| id | doaj.art-b986b8135eb74eb68e8a54319c37a809 |
| institution | Directory Open Access Journal |
| issn | 2364-5504 |
| language | English |
| last_indexed | 2024-04-13T23:12:11Z |
| publishDate | 2021-10-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Current Directions in Biomedical Engineering |
| spelling | doaj.art-b986b8135eb74eb68e8a54319c37a8092022-12-22T02:25:32ZengDe GruyterCurrent Directions in Biomedical Engineering2364-55042021-10-017240741010.1515/cdbme-2021-21033D Printed Individualized Frontal Neo-Ostium Implant in Endoscopic Sinus Surgery – a Proof of Concept StudyGao Ziwen0Matin Farnaz1Wei Chunjiang2Lenarz Thomas3Weber Constantin4John Samuel5Scheper Verena6Hannover Medical School, Carl-Neuberg Str.1, 30625Hannover, GermanyDepartment of Otolaryngology Hannover Medical School,Hannover, GermanyDepartment of Otolaryngology Hannover Medical School,Hannover, GermanyDepartment of Otolaryngology Hannover Medical School,Hannover, GermanyCluster of Excellence”Hearing4all” EXC 1077/1, Oldenburg/Hannover, German Research Foundation,Bonn, GermanyHörSys,Hannover, GermanyHannover Medical School, Carl-Neuberg Str.1, 30625Hannover, Germany3D-printing paves the way for personalized drug therapy via implants individualized for the patient specific anatomy in chronic paranasal sinus diseases. This study brings together the workflow of modeling, manufacturing, and sterilization of 3D-printed individualized frontal neo-ostium implants (FOI) for optimization of Endoscopic Sinus Surgery (ESS) and validates the implantability of the printed devices. The study sample consisted of six adult human cadavers. Digital volume tomography (DVT) images were taken before and after ESS. The FOI models were based on the post-ESS anatomy. The area to be implanted was analysed in the preand post-ESS DVT images for volume and surface area. A specialized surgeon in rhinology judged the implantability of the 3D-printed FOI. The mean values of volume and surface area tended to be larger in the post-operation situs than in preoperation DVT images and we are therefore not yet convinced that pre-operation images will reflect the correct anatomy for the personalization of the FOI. The workflow of manufacturing and implantation of individualized 3D-printed sterile FOI is established but future studies are needed for further improvement.https://doi.org/10.1515/cdbme-2021-21033d printingendoscopic sinus surgeryindividualized neo-ostium implantsuv-siliconeindividualized therapypersonalized medicinedrug eluting deviceimplantability |
| spellingShingle | Gao Ziwen Matin Farnaz Wei Chunjiang Lenarz Thomas Weber Constantin John Samuel Scheper Verena 3D Printed Individualized Frontal Neo-Ostium Implant in Endoscopic Sinus Surgery – a Proof of Concept Study Current Directions in Biomedical Engineering 3d printing endoscopic sinus surgery individualized neo-ostium implants uv-silicone individualized therapy personalized medicine drug eluting device implantability |
| title | 3D Printed Individualized Frontal Neo-Ostium Implant in Endoscopic Sinus Surgery – a Proof of Concept Study |
| title_full | 3D Printed Individualized Frontal Neo-Ostium Implant in Endoscopic Sinus Surgery – a Proof of Concept Study |
| title_fullStr | 3D Printed Individualized Frontal Neo-Ostium Implant in Endoscopic Sinus Surgery – a Proof of Concept Study |
| title_full_unstemmed | 3D Printed Individualized Frontal Neo-Ostium Implant in Endoscopic Sinus Surgery – a Proof of Concept Study |
| title_short | 3D Printed Individualized Frontal Neo-Ostium Implant in Endoscopic Sinus Surgery – a Proof of Concept Study |
| title_sort | 3d printed individualized frontal neo ostium implant in endoscopic sinus surgery a proof of concept study |
| topic | 3d printing endoscopic sinus surgery individualized neo-ostium implants uv-silicone individualized therapy personalized medicine drug eluting device implantability |
| url | https://doi.org/10.1515/cdbme-2021-2103 |
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