Primary prophylaxis of venous thromboembolic disease with direct oral anticoagulants in patients with severe inherited thrombophilia
Abstract Direct oral anticoagulants (DOACs) are widely used in several indications, but data on their efficacy and safety in individuals affected by severe inherited thrombophilia, yet without any personal history of thrombosis, is lacking. Severe inherited thrombophilia abnormalities, especially an...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-02-01
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| Series: | Research and Practice in Thrombosis and Haemostasis |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rth2.12479 |
| _version_ | 1797707747752411136 |
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| author | Evelien Krumb Cedric Hermans |
| author_facet | Evelien Krumb Cedric Hermans |
| author_sort | Evelien Krumb |
| collection | DOAJ |
| description | Abstract Direct oral anticoagulants (DOACs) are widely used in several indications, but data on their efficacy and safety in individuals affected by severe inherited thrombophilia, yet without any personal history of thrombosis, is lacking. Severe inherited thrombophilia abnormalities, especially antithrombin deficiency, confer a higher risk of developing venous thromboembolism (VTE) than is the case in the general population. In this article, we propose primary prevention with low‐dose DOACs for certain patients with severe inherited thrombophilia but without any personal history of VTE, while taking into consideration the type of thrombophilia, family history, comorbidities, and bleeding risk. |
| first_indexed | 2024-03-12T06:10:59Z |
| format | Article |
| id | doaj.art-b98837fde6be4122be80111b17cb808e |
| institution | Directory Open Access Journal |
| issn | 2475-0379 |
| language | English |
| last_indexed | 2024-03-12T06:10:59Z |
| publishDate | 2021-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Research and Practice in Thrombosis and Haemostasis |
| spelling | doaj.art-b98837fde6be4122be80111b17cb808e2023-09-03T03:02:56ZengElsevierResearch and Practice in Thrombosis and Haemostasis2475-03792021-02-015226126410.1002/rth2.12479Primary prophylaxis of venous thromboembolic disease with direct oral anticoagulants in patients with severe inherited thrombophiliaEvelien Krumb0Cedric Hermans1Hemostasis and Thrombosis Unit Division of Hematology Cliniques Universitaires Saint‐LucUniversité Catholique de Louvain (UCLouvain) Brussels BelgiumHemostasis and Thrombosis Unit Division of Hematology Cliniques Universitaires Saint‐LucUniversité Catholique de Louvain (UCLouvain) Brussels BelgiumAbstract Direct oral anticoagulants (DOACs) are widely used in several indications, but data on their efficacy and safety in individuals affected by severe inherited thrombophilia, yet without any personal history of thrombosis, is lacking. Severe inherited thrombophilia abnormalities, especially antithrombin deficiency, confer a higher risk of developing venous thromboembolism (VTE) than is the case in the general population. In this article, we propose primary prevention with low‐dose DOACs for certain patients with severe inherited thrombophilia but without any personal history of VTE, while taking into consideration the type of thrombophilia, family history, comorbidities, and bleeding risk.https://doi.org/10.1002/rth2.12479anticoagulantsantithrombin deficiencyapixabanrivaroxabanthrombophiliavenous thromboembolism |
| spellingShingle | Evelien Krumb Cedric Hermans Primary prophylaxis of venous thromboembolic disease with direct oral anticoagulants in patients with severe inherited thrombophilia Research and Practice in Thrombosis and Haemostasis anticoagulants antithrombin deficiency apixaban rivaroxaban thrombophilia venous thromboembolism |
| title | Primary prophylaxis of venous thromboembolic disease with direct oral anticoagulants in patients with severe inherited thrombophilia |
| title_full | Primary prophylaxis of venous thromboembolic disease with direct oral anticoagulants in patients with severe inherited thrombophilia |
| title_fullStr | Primary prophylaxis of venous thromboembolic disease with direct oral anticoagulants in patients with severe inherited thrombophilia |
| title_full_unstemmed | Primary prophylaxis of venous thromboembolic disease with direct oral anticoagulants in patients with severe inherited thrombophilia |
| title_short | Primary prophylaxis of venous thromboembolic disease with direct oral anticoagulants in patients with severe inherited thrombophilia |
| title_sort | primary prophylaxis of venous thromboembolic disease with direct oral anticoagulants in patients with severe inherited thrombophilia |
| topic | anticoagulants antithrombin deficiency apixaban rivaroxaban thrombophilia venous thromboembolism |
| url | https://doi.org/10.1002/rth2.12479 |
| work_keys_str_mv | AT evelienkrumb primaryprophylaxisofvenousthromboembolicdiseasewithdirectoralanticoagulantsinpatientswithsevereinheritedthrombophilia AT cedrichermans primaryprophylaxisofvenousthromboembolicdiseasewithdirectoralanticoagulantsinpatientswithsevereinheritedthrombophilia |