Embryonic diapause due to high glucose is related to changes in glycolysis and oxidative phosphorylation, as well as abnormalities in the TCA cycle and amino acid metabolism

Embryonic diapause due to high glucose is related to changes in glycolysis and oxidative phosphorylation, as well as abnormalities in the TCA cycle and amino acid metabolism

IntroductionThe adverse effects of high glucose on embryos can be traced to the preimplantation stage. This study aimed to observe the effect of high glucose on early-stage embryos. Methods and resultsSeven-week-old ICR female mice were superovulated and mated, and the zygotes were collected. The zy...

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Bibliographic Details
Main Authors: Jiewei Hong, Hongxuan Tong, Xuan Wang, Xiaoyan Lv, Lijuan He, Xuezhi Yang, Yingli Wang, Kaixia Xu, Qi Liang, Qianjin Feng, Tingli Niu, Xin Niu, Yu Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Endocrinology
Subjects:
embryo arrest
high glucose
embryo metabolism
in vitro
GLUTs
GC-MS
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1135837/full

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