Mendelian randomisation study of body composition and depression in people of East Asian ancestry highlights potential setting-specific causality

Mendelian randomisation study of body composition and depression in people of East Asian ancestry highlights potential setting-specific causality

Abstract Background Extensive evidence links higher body mass index (BMI) to higher odds of depression in people of European ancestry. However, our understanding of the relationship across different settings and ancestries is limited. Here, we test the relationship between body composition and depre...

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Bibliographic Details
Main Authors: Jessica O’Loughlin, Francesco Casanova, Zammy Fairhurst-Hunter, Amanda Hughes, Jack Bowden, Edward R. Watkins, Rachel M. Freathy, Iona Y. Millwood, Kuang Lin, Zhengming Chen, Liming Li, Jun Lv, China Kadoorie Biobank Collaborative Group, Robin G. Walters, Laura D. Howe, Karoline Kuchenbaecker, Jessica Tyrrell
Format: Article
Language:English
Published: BMC 2023-02-01
Series:BMC Medicine
Subjects:
Mendelian randomisation
BMI
Depression
East Asian ancestry
Public health
Setting-specific causality
Online Access:https://doi.org/10.1186/s12916-023-02735-8

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