Elimination of Reference Mapping Bias Reveals Robust Immune Related Allele-Specific Expression in Crossbred Sheep

Elimination of Reference Mapping Bias Reveals Robust Immune Related Allele-Specific Expression in Crossbred Sheep

Pervasive allelic variation at both gene and single nucleotide level (SNV) between individuals is commonly associated with complex traits in humans and animals. Allele-specific expression (ASE) analysis, using RNA-Seq, can provide a detailed annotation of allelic imbalance and infer the existence of...

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Bibliographic Details
Main Authors: Mazdak Salavati, Stephen J. Bush, Sergio Palma-Vera, Mary E. B. McCulloch, David A. Hume, Emily L. Clark
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Genetics
Subjects:
allele-specific expression
mapping bias
RNA-Seq
sheep
transcriptome
WASP
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00863/full

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