Inhibition of Glutamate Release from Rat Cortical Nerve Terminals by Dehydrocorydaline, an Alkaloid from <i>Corydalis yanhusuo</i>

Inhibition of Glutamate Release from Rat Cortical Nerve Terminals by Dehydrocorydaline, an Alkaloid from <i>Corydalis yanhusuo</i>

Excessive release of glutamate induces excitotoxicity and causes neuronal damage in several neurodegenerative diseases. Natural products have emerged as potential neuroprotective agents for preventing and treating neurological disorders. Dehydrocorydaline (DHC), an active alkaloid compound isolated...

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Bibliographic Details
Main Authors: Tzu-Yu Lin, I-Yen Chen, Ming-Yi Lee, Cheng-Wei Lu, Kuan-Ming Chiu, Su-Jane Wang
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Molecules
Subjects:
dehydrocorydaline
glutamate release
Ca<sup>2+</sup> influx
synaptosomes
neuroprotection
MAPK/ERK/synapsin I
Online Access:https://www.mdpi.com/1420-3049/27/3/960

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