The Association of Trp64Arg Polymorphism in the Beta-Adrenergic Receptor With Insulin Resistance: Meta-Analysis
BackgroundInsulin resistance is a metabolic disorder that occurs in type 2 diabetes mellitus and obesity. Genetic factors such as β3-adrenoceptor polymorphism (Trp64Arg) may be involved in IR and insulin secretion. However, their association is controversial. Therefore, the current meta-analysis was...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2021.708139/full |
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| author | Hai-Dan Wang Cai-Shun Zhang Man-Wen Li Qian Lin Qing Zhang De-Feng Liu Zheng-Ye Ma Jing Dong Jing Dong |
| author_facet | Hai-Dan Wang Cai-Shun Zhang Man-Wen Li Qian Lin Qing Zhang De-Feng Liu Zheng-Ye Ma Jing Dong Jing Dong |
| author_sort | Hai-Dan Wang |
| collection | DOAJ |
| description | BackgroundInsulin resistance is a metabolic disorder that occurs in type 2 diabetes mellitus and obesity. Genetic factors such as β3-adrenoceptor polymorphism (Trp64Arg) may be involved in IR and insulin secretion. However, their association is controversial. Therefore, the current meta-analysis was conducted to clarify the relationship between the Trp64Arg and IR.MethodsThe literature search was performed in PubMed, Embase, and Web of Science using the keywords “Receptors, Adrenergic, beta-3, Receptors, Adrenergic, Insulin Resistance, Protein-Coupled Receptor Kinase 3” from 2005 to February 7, 2021. We used a random-effects model to calculate the pooled effect size. We conducted subgroup analysis and regression analysis to identify sources of heterogeneity; and Egger’s test and funnel plot were used to test publication bias. Finally, we conducted a sensitivity analysis.ResultsWe included eight papers with 1,586 subjects. There was a positive correlation between Trp64Arg mutation and insulin level (standardized mean difference = 0.20, 95% confidence intervals: 0.00 to 0.39, I2 = 57.6%, p = 0.016). However, there was no association between Trp64Arg and the homeostasis model (HOMA-IR) assessment. Egger’s tests showed no publication bias; the sensitivity analysis showed that our results were stable. Regression analysis revealed no source of heterogeneity.ConclusionTrp64Arg may be associated with IR. European ancestry, obesity, plasma insulin level, and test status may be potential factors affecting the relationship between Trp64Arg and IR. |
| first_indexed | 2024-12-15T00:02:46Z |
| format | Article |
| id | doaj.art-b98e5f5cc51c45b4afd9b6b6aa8dd5da |
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| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-15T00:02:46Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-b98e5f5cc51c45b4afd9b6b6aa8dd5da2022-12-21T22:42:51ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-08-011210.3389/fendo.2021.708139708139The Association of Trp64Arg Polymorphism in the Beta-Adrenergic Receptor With Insulin Resistance: Meta-AnalysisHai-Dan Wang0Cai-Shun Zhang1Man-Wen Li2Qian Lin3Qing Zhang4De-Feng Liu5Zheng-Ye Ma6Jing Dong7Jing Dong8Special Medicine Department, Medical College, Qingdao University, Qingdao, ChinaSpecial Medicine Department, Medical College, Qingdao University, Qingdao, ChinaSpecial Medicine Department, Medical College, Qingdao University, Qingdao, ChinaSpecial Medicine Department, Medical College, Qingdao University, Qingdao, ChinaSpecial Medicine Department, Medical College, Qingdao University, Qingdao, ChinaClinical Medicine Department, Medical College, Qingdao University, Qingdao, ChinaClinical Medicine Department, Medical College, Qingdao University, Qingdao, ChinaSpecial Medicine Department, Medical College, Qingdao University, Qingdao, ChinaPhysiology Department, Medical College, Qingdao University, Qingdao, ChinaBackgroundInsulin resistance is a metabolic disorder that occurs in type 2 diabetes mellitus and obesity. Genetic factors such as β3-adrenoceptor polymorphism (Trp64Arg) may be involved in IR and insulin secretion. However, their association is controversial. Therefore, the current meta-analysis was conducted to clarify the relationship between the Trp64Arg and IR.MethodsThe literature search was performed in PubMed, Embase, and Web of Science using the keywords “Receptors, Adrenergic, beta-3, Receptors, Adrenergic, Insulin Resistance, Protein-Coupled Receptor Kinase 3” from 2005 to February 7, 2021. We used a random-effects model to calculate the pooled effect size. We conducted subgroup analysis and regression analysis to identify sources of heterogeneity; and Egger’s test and funnel plot were used to test publication bias. Finally, we conducted a sensitivity analysis.ResultsWe included eight papers with 1,586 subjects. There was a positive correlation between Trp64Arg mutation and insulin level (standardized mean difference = 0.20, 95% confidence intervals: 0.00 to 0.39, I2 = 57.6%, p = 0.016). However, there was no association between Trp64Arg and the homeostasis model (HOMA-IR) assessment. Egger’s tests showed no publication bias; the sensitivity analysis showed that our results were stable. Regression analysis revealed no source of heterogeneity.ConclusionTrp64Arg may be associated with IR. European ancestry, obesity, plasma insulin level, and test status may be potential factors affecting the relationship between Trp64Arg and IR.https://www.frontiersin.org/articles/10.3389/fendo.2021.708139/fullTrp64Arginsulin resistanceβ3-adrenergic receptor genemeta-analysissubgroup analysis |
| spellingShingle | Hai-Dan Wang Cai-Shun Zhang Man-Wen Li Qian Lin Qing Zhang De-Feng Liu Zheng-Ye Ma Jing Dong Jing Dong The Association of Trp64Arg Polymorphism in the Beta-Adrenergic Receptor With Insulin Resistance: Meta-Analysis Frontiers in Endocrinology Trp64Arg insulin resistance β3-adrenergic receptor gene meta-analysis subgroup analysis |
| title | The Association of Trp64Arg Polymorphism in the Beta-Adrenergic Receptor With Insulin Resistance: Meta-Analysis |
| title_full | The Association of Trp64Arg Polymorphism in the Beta-Adrenergic Receptor With Insulin Resistance: Meta-Analysis |
| title_fullStr | The Association of Trp64Arg Polymorphism in the Beta-Adrenergic Receptor With Insulin Resistance: Meta-Analysis |
| title_full_unstemmed | The Association of Trp64Arg Polymorphism in the Beta-Adrenergic Receptor With Insulin Resistance: Meta-Analysis |
| title_short | The Association of Trp64Arg Polymorphism in the Beta-Adrenergic Receptor With Insulin Resistance: Meta-Analysis |
| title_sort | association of trp64arg polymorphism in the beta adrenergic receptor with insulin resistance meta analysis |
| topic | Trp64Arg insulin resistance β3-adrenergic receptor gene meta-analysis subgroup analysis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2021.708139/full |
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