Maternal smoking status before and during pregnancy and bronchial asthma at 3 years of age: a prospective cohort study
Abstract The association between maternal pre-pregnancy smoking status and asthma risk is unclear. This study aimed to investigate the association between pre- and post-pregnancy maternal smoking status and bronchial asthma at 3 years of age in a large birth cohort. Data of 75,411 mother–child pairs...
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Nature Portfolio
2023-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-30304-9 |
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| author | Kunio Miyake Megumi Kushima Ryoji Shinohara Sayaka Horiuchi Sanae Otawa Yuka Akiyama Tadao Ooka Reiji Kojima Hiroshi Yokomichi Zentaro Yamagata The Japan Environment and Children’s Study Group |
| author_facet | Kunio Miyake Megumi Kushima Ryoji Shinohara Sayaka Horiuchi Sanae Otawa Yuka Akiyama Tadao Ooka Reiji Kojima Hiroshi Yokomichi Zentaro Yamagata The Japan Environment and Children’s Study Group |
| author_sort | Kunio Miyake |
| collection | DOAJ |
| description | Abstract The association between maternal pre-pregnancy smoking status and asthma risk is unclear. This study aimed to investigate the association between pre- and post-pregnancy maternal smoking status and bronchial asthma at 3 years of age in a large birth cohort. Data of 75,411 mother–child pairs from the Japan Environment and Children's Study (JECS) were analysed using multivariate logistic regression analysis. Overall, 7.2% of the children had bronchial asthma. The maternal smoking status before childbirth was as follows: Never = 60.0%, Quit before recognising current pregnancy = 24.1%, Quit after finding out about current pregnancy = 12.3%, and Still smoking = 3.6%. Children of mothers who sustained smoking during pregnancy had an increased risk of bronchial asthma at 3 years of age even after adjusting for pre- and postnatal covariates (adjusted odds ratio [aOR] 1.34, 95% confidence interval [CI] 1.15–1.56). Children of mothers who quit before (aOR 1.09, 95% CI 1.02–1.18) or after (aOR 1.11, 95% CI 1.01–1.23) recognising the current pregnancy had an increased risk of bronchial asthma at 3 years of age. Maternal smoking throughout pregnancy and smoking exposure pre-pregnancy or in early pregnancy increases the risk of bronchial asthma in children. |
| first_indexed | 2024-04-09T22:58:45Z |
| format | Article |
| id | doaj.art-b98ee341765e4817bb177b1cdb2a5d32 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T22:58:45Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-b98ee341765e4817bb177b1cdb2a5d322023-03-22T11:06:05ZengNature PortfolioScientific Reports2045-23222023-02-011311810.1038/s41598-023-30304-9Maternal smoking status before and during pregnancy and bronchial asthma at 3 years of age: a prospective cohort studyKunio Miyake0Megumi Kushima1Ryoji Shinohara2Sayaka Horiuchi3Sanae Otawa4Yuka Akiyama5Tadao Ooka6Reiji Kojima7Hiroshi Yokomichi8Zentaro Yamagata9The Japan Environment and Children’s Study GroupDepartment of Health Sciences, School of Medicine, University of YamanashiCenter for Birth Cohort Studies, University of YamanashiCenter for Birth Cohort Studies, University of YamanashiCenter for Birth Cohort Studies, University of YamanashiCenter for Birth Cohort Studies, University of YamanashiDepartment of Health Sciences, School of Medicine, University of YamanashiDepartment of Health Sciences, School of Medicine, University of YamanashiDepartment of Health Sciences, School of Medicine, University of YamanashiDepartment of Health Sciences, School of Medicine, University of YamanashiDepartment of Health Sciences, School of Medicine, University of YamanashiAbstract The association between maternal pre-pregnancy smoking status and asthma risk is unclear. This study aimed to investigate the association between pre- and post-pregnancy maternal smoking status and bronchial asthma at 3 years of age in a large birth cohort. Data of 75,411 mother–child pairs from the Japan Environment and Children's Study (JECS) were analysed using multivariate logistic regression analysis. Overall, 7.2% of the children had bronchial asthma. The maternal smoking status before childbirth was as follows: Never = 60.0%, Quit before recognising current pregnancy = 24.1%, Quit after finding out about current pregnancy = 12.3%, and Still smoking = 3.6%. Children of mothers who sustained smoking during pregnancy had an increased risk of bronchial asthma at 3 years of age even after adjusting for pre- and postnatal covariates (adjusted odds ratio [aOR] 1.34, 95% confidence interval [CI] 1.15–1.56). Children of mothers who quit before (aOR 1.09, 95% CI 1.02–1.18) or after (aOR 1.11, 95% CI 1.01–1.23) recognising the current pregnancy had an increased risk of bronchial asthma at 3 years of age. Maternal smoking throughout pregnancy and smoking exposure pre-pregnancy or in early pregnancy increases the risk of bronchial asthma in children.https://doi.org/10.1038/s41598-023-30304-9 |
| spellingShingle | Kunio Miyake Megumi Kushima Ryoji Shinohara Sayaka Horiuchi Sanae Otawa Yuka Akiyama Tadao Ooka Reiji Kojima Hiroshi Yokomichi Zentaro Yamagata The Japan Environment and Children’s Study Group Maternal smoking status before and during pregnancy and bronchial asthma at 3 years of age: a prospective cohort study Scientific Reports |
| title | Maternal smoking status before and during pregnancy and bronchial asthma at 3 years of age: a prospective cohort study |
| title_full | Maternal smoking status before and during pregnancy and bronchial asthma at 3 years of age: a prospective cohort study |
| title_fullStr | Maternal smoking status before and during pregnancy and bronchial asthma at 3 years of age: a prospective cohort study |
| title_full_unstemmed | Maternal smoking status before and during pregnancy and bronchial asthma at 3 years of age: a prospective cohort study |
| title_short | Maternal smoking status before and during pregnancy and bronchial asthma at 3 years of age: a prospective cohort study |
| title_sort | maternal smoking status before and during pregnancy and bronchial asthma at 3 years of age a prospective cohort study |
| url | https://doi.org/10.1038/s41598-023-30304-9 |
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