VHPKQHR peptide modified magnetic mesoporous nanoparticles for MRI detection of atherosclerosis lesions
Mortality attributable to atherosclerosis can be reduced significantly with timely diagnosis and treatment. It is meaningful to find a proper way to diagnose and prevent the progression of atherosclerosis. Vascular cell adhesion molecule-1 (VCAM-1) expressed by endothelial cells is a prominent marke...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-12-01
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| Series: | Artificial Cells, Nanomedicine, and Biotechnology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21691401.2019.1626411 |
| _version_ | 1811291891594952704 |
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| author | Wan Xu Shuihua Zhang Quan Zhou Wenli Chen |
| author_facet | Wan Xu Shuihua Zhang Quan Zhou Wenli Chen |
| author_sort | Wan Xu |
| collection | DOAJ |
| description | Mortality attributable to atherosclerosis can be reduced significantly with timely diagnosis and treatment. It is meaningful to find a proper way to diagnose and prevent the progression of atherosclerosis. Vascular cell adhesion molecule-1 (VCAM-1) expressed by endothelial cells is a prominent marker of atherosclerotic plaques. There are a number of researches on VCAM-1 based probes for targeted imaging, but rarely on a system with both targeting and drug delivery. Here, we report a novel magnetic mesoporous silicon nanoparticle that is capable of drug delivery and targeting at atherosclerosis plaque. The nanoparticles were constructed using incorporated FITC (fluorescein isothiocyanate) and VHPKQHR peptide into Fe3O4@SiO2 (FITC-VHP-Fe3O4@SiO2). The FITC-VHP-Fe3O4@SiO2 nanoparticles showed great morphological characteristics, superior targeting ability, low toxicity and good biocompatibility in vitro and in vivo. The in vivo experiments showed that FITC-VHP-Fe3O4@SiO2 is a superior contrast agent of magnetic resonance imaging (MRI) for diagnosis of atherosclerosis plaques. |
| first_indexed | 2024-04-13T04:36:13Z |
| format | Article |
| id | doaj.art-b9926c6d2cc04122a36d9d37e5d1185a |
| institution | Directory Open Access Journal |
| issn | 2169-1401 2169-141X |
| language | English |
| last_indexed | 2024-04-13T04:36:13Z |
| publishDate | 2019-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Artificial Cells, Nanomedicine, and Biotechnology |
| spelling | doaj.art-b9926c6d2cc04122a36d9d37e5d1185a2022-12-22T03:02:09ZengTaylor & Francis GroupArtificial Cells, Nanomedicine, and Biotechnology2169-14012169-141X2019-12-014712440244810.1080/21691401.2019.1626411VHPKQHR peptide modified magnetic mesoporous nanoparticles for MRI detection of atherosclerosis lesionsWan Xu0Shuihua Zhang1Quan Zhou2Wenli Chen3MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, South China Normal University, Guangzhou, ChinaGuangzhou Universal Medical Imaging Diagnostic Center, Universal Medical Imaging, Guangzhou, ChinaDepartment of Radiology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, ChinaMOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, South China Normal University, Guangzhou, ChinaMortality attributable to atherosclerosis can be reduced significantly with timely diagnosis and treatment. It is meaningful to find a proper way to diagnose and prevent the progression of atherosclerosis. Vascular cell adhesion molecule-1 (VCAM-1) expressed by endothelial cells is a prominent marker of atherosclerotic plaques. There are a number of researches on VCAM-1 based probes for targeted imaging, but rarely on a system with both targeting and drug delivery. Here, we report a novel magnetic mesoporous silicon nanoparticle that is capable of drug delivery and targeting at atherosclerosis plaque. The nanoparticles were constructed using incorporated FITC (fluorescein isothiocyanate) and VHPKQHR peptide into Fe3O4@SiO2 (FITC-VHP-Fe3O4@SiO2). The FITC-VHP-Fe3O4@SiO2 nanoparticles showed great morphological characteristics, superior targeting ability, low toxicity and good biocompatibility in vitro and in vivo. The in vivo experiments showed that FITC-VHP-Fe3O4@SiO2 is a superior contrast agent of magnetic resonance imaging (MRI) for diagnosis of atherosclerosis plaques.https://www.tandfonline.com/doi/10.1080/21691401.2019.1626411Magnetic mesoporous nanoparticlespeptidetargetingatherosclerosis |
| spellingShingle | Wan Xu Shuihua Zhang Quan Zhou Wenli Chen VHPKQHR peptide modified magnetic mesoporous nanoparticles for MRI detection of atherosclerosis lesions Artificial Cells, Nanomedicine, and Biotechnology Magnetic mesoporous nanoparticles peptide targeting atherosclerosis |
| title | VHPKQHR peptide modified magnetic mesoporous nanoparticles for MRI detection of atherosclerosis lesions |
| title_full | VHPKQHR peptide modified magnetic mesoporous nanoparticles for MRI detection of atherosclerosis lesions |
| title_fullStr | VHPKQHR peptide modified magnetic mesoporous nanoparticles for MRI detection of atherosclerosis lesions |
| title_full_unstemmed | VHPKQHR peptide modified magnetic mesoporous nanoparticles for MRI detection of atherosclerosis lesions |
| title_short | VHPKQHR peptide modified magnetic mesoporous nanoparticles for MRI detection of atherosclerosis lesions |
| title_sort | vhpkqhr peptide modified magnetic mesoporous nanoparticles for mri detection of atherosclerosis lesions |
| topic | Magnetic mesoporous nanoparticles peptide targeting atherosclerosis |
| url | https://www.tandfonline.com/doi/10.1080/21691401.2019.1626411 |
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