Inflammasome genes polymorphisms and susceptibility to gout. Is there a link?
Background: The inflammatory response in gout disease is induced by the activation of NLR family pyrin domain-containing 3 (NLPR3) signaling pathway mediated by IL-1β release. Objective: The objective of the study was to determine the association between single nucleotide polymorphisms (SNPs) within...
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| Format: | Article |
| Language: | English |
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Permanyer
2022-07-01
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| Series: | Revista de Investigación Clínica |
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| Online Access: | https://www.clinicalandtranslationalinvestigation.com/frame_esp.php?id=419 |
| _version_ | 1811237331838959616 |
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| author | Denise Clavijo-Cornejo Alberto López-Reyes Esteban Cruz-Arenas Leonor Jacobo-Albavera Daniel Rivera-Tlaltzicapa Adriana Francisco-Balderas Mayra Domínguez-Pérez Pablo Romero-Morelos Janitzia Vázquez-Mellado Luis H. Silveira Carlos Pineda Gabriela Martínez-Nava Marwin Gutierrez |
| author_facet | Denise Clavijo-Cornejo Alberto López-Reyes Esteban Cruz-Arenas Leonor Jacobo-Albavera Daniel Rivera-Tlaltzicapa Adriana Francisco-Balderas Mayra Domínguez-Pérez Pablo Romero-Morelos Janitzia Vázquez-Mellado Luis H. Silveira Carlos Pineda Gabriela Martínez-Nava Marwin Gutierrez |
| author_sort | Denise Clavijo-Cornejo |
| collection | DOAJ |
| description | Background: The inflammatory response in gout disease is induced by the activation of NLR family pyrin domain-containing 3 (NLPR3) signaling pathway mediated by IL-1β release. Objective: The objective of the study was to determine the association between single nucleotide polymorphisms (SNPs) within NLRP3 inflammasome genes and gout susceptibility. Methods: Mexican patients with gout from the National Rehabilitation Institute and General Hospital of Mexico were enrolled. A healthy control group was also included. We analyzed the frequency and allelic distribution of eight SNPs from seven different genes within the NLRP3 inflammasome signaling pathway: TLR4 rs2149356, CD14 rs2569190, NLRP3 rs3806268, NLRP3 rs10754558, CARD8 rs2043211, IL-1β rs1143623, P2RX7 rs3751142, and PPARGC1B rs45520937 SNPs. Results: We found that the SNP rs45520937 of PPARGC1B was associated with the risk of developing gout when it was analyzed using the dominant model (Odds ratio [OR] = 2.30; 95% confidence interval [CI]: 1.09-4.86; p = 0.030), and it is proposed that the adaptor molecule CD14 rs2569190 polymorphism could be associated with a lower risk of gout under an additive model (OR= 0.41;95% CI: 0.16-1.05; p = 0.064). No significant associations were identified for the remaining SNPs. Conclusion: Our findings suggest that the PPARGC1B rs45520937 SNP is associated with gout susceptibility.
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| first_indexed | 2024-04-12T12:22:46Z |
| format | Article |
| id | doaj.art-b9934b6715fd4dd9aa2ae6e5a72eb3ad |
| institution | Directory Open Access Journal |
| issn | 0034-8376 2564-8896 |
| language | English |
| last_indexed | 2024-04-12T12:22:46Z |
| publishDate | 2022-07-01 |
| publisher | Permanyer |
| record_format | Article |
| series | Revista de Investigación Clínica |
| spelling | doaj.art-b9934b6715fd4dd9aa2ae6e5a72eb3ad2022-12-22T03:33:15ZengPermanyerRevista de Investigación Clínica0034-83762564-88962022-07-0174310.24875/RIC.21000603Inflammasome genes polymorphisms and susceptibility to gout. Is there a link?Denise Clavijo-Cornejo0Alberto López-Reyes1Esteban Cruz-Arenas2Leonor Jacobo-Albavera3Daniel Rivera-Tlaltzicapa4Adriana Francisco-Balderas5Mayra Domínguez-Pérez6Pablo Romero-Morelos7Janitzia Vázquez-Mellado8Luis H. Silveira9Carlos Pineda10Gabriela Martínez-Nava11Marwin Gutierrez12Division of Musculoskeletal and Rheumatic Diseases, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City, MexicoGerosciences Laboratory, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City, MexicoHospital Epidemiological Surveillance Unit, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City, MexicoLaboratory of Cardiovascular Genomics, Instituto Nacional de Medicina Genómica, Mexico City, MexicoUniversidad Autónoma Metropolitana, Mexico City, MexicoGraduate Studies Department, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City, MexicoUniversidad Estatal del Valle de Ecatepec, Mexico City, MexicoRheumatology Department, Hospital General de México, Mexico City, MexicoRheumatology Department, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoSynovial Fluid Laboratory, Instituto Nacional de Rehabilitación LGII, Mexico City, MexicoDivision of Musculoskeletal and Rheumatic Diseases, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City, MexicoSynovial Fluid Laboratory, Instituto Nacional de Rehabilitación LGII, Mexico City, MexicoDivision of Musculoskeletal and Rheumatic Diseases, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City, MexicoBackground: The inflammatory response in gout disease is induced by the activation of NLR family pyrin domain-containing 3 (NLPR3) signaling pathway mediated by IL-1β release. Objective: The objective of the study was to determine the association between single nucleotide polymorphisms (SNPs) within NLRP3 inflammasome genes and gout susceptibility. Methods: Mexican patients with gout from the National Rehabilitation Institute and General Hospital of Mexico were enrolled. A healthy control group was also included. We analyzed the frequency and allelic distribution of eight SNPs from seven different genes within the NLRP3 inflammasome signaling pathway: TLR4 rs2149356, CD14 rs2569190, NLRP3 rs3806268, NLRP3 rs10754558, CARD8 rs2043211, IL-1β rs1143623, P2RX7 rs3751142, and PPARGC1B rs45520937 SNPs. Results: We found that the SNP rs45520937 of PPARGC1B was associated with the risk of developing gout when it was analyzed using the dominant model (Odds ratio [OR] = 2.30; 95% confidence interval [CI]: 1.09-4.86; p = 0.030), and it is proposed that the adaptor molecule CD14 rs2569190 polymorphism could be associated with a lower risk of gout under an additive model (OR= 0.41;95% CI: 0.16-1.05; p = 0.064). No significant associations were identified for the remaining SNPs. Conclusion: Our findings suggest that the PPARGC1B rs45520937 SNP is associated with gout susceptibility. https://www.clinicalandtranslationalinvestigation.com/frame_esp.php?id=419Gout. SNPs. NLRP3. Inflammasome. |
| spellingShingle | Denise Clavijo-Cornejo Alberto López-Reyes Esteban Cruz-Arenas Leonor Jacobo-Albavera Daniel Rivera-Tlaltzicapa Adriana Francisco-Balderas Mayra Domínguez-Pérez Pablo Romero-Morelos Janitzia Vázquez-Mellado Luis H. Silveira Carlos Pineda Gabriela Martínez-Nava Marwin Gutierrez Inflammasome genes polymorphisms and susceptibility to gout. Is there a link? Revista de Investigación Clínica Gout. SNPs. NLRP3. Inflammasome. |
| title | Inflammasome genes polymorphisms and susceptibility to gout. Is there a link? |
| title_full | Inflammasome genes polymorphisms and susceptibility to gout. Is there a link? |
| title_fullStr | Inflammasome genes polymorphisms and susceptibility to gout. Is there a link? |
| title_full_unstemmed | Inflammasome genes polymorphisms and susceptibility to gout. Is there a link? |
| title_short | Inflammasome genes polymorphisms and susceptibility to gout. Is there a link? |
| title_sort | inflammasome genes polymorphisms and susceptibility to gout is there a link |
| topic | Gout. SNPs. NLRP3. Inflammasome. |
| url | https://www.clinicalandtranslationalinvestigation.com/frame_esp.php?id=419 |
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