Circle of Willis variants are not associated with thrombectomy outcomes
Background The circle of Willis (COW) is part of the brain collateral system. The absence of COW segments may affect functional outcome in patients with ischaemic stroke undergoing endovascular therapy.Methods In 182 patients in the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
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| Series: | Stroke and Vascular Neurology |
| Online Access: | https://svn.bmj.com/content/early/2020/10/11/svn-2020-000491.full |
| _version_ | 1818554336134823936 |
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| author | Gregory W Albers Christian Enzinger Maarten Lansberg Soren Christensen Thomas Seifert-Held Katharina Eberhard Edith Hofer |
| author_facet | Gregory W Albers Christian Enzinger Maarten Lansberg Soren Christensen Thomas Seifert-Held Katharina Eberhard Edith Hofer |
| author_sort | Gregory W Albers |
| collection | DOAJ |
| description | Background The circle of Willis (COW) is part of the brain collateral system. The absence of COW segments may affect functional outcome in patients with ischaemic stroke undergoing endovascular therapy.Methods In 182 patients in the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution 2 Study and the CT Perfusion to Predict Response to Recanalisation in Ischaemic Stroke Project, COW anatomy was evaluated on postinterventional magnetic resonance angiography. The absence of the posterior communicating artery or the first segments of posterior or anterior cerebral arteries ipsilateral to the ischaemic infarction was rated as an incomplete COW. Logistic regression was applied to evaluate an association with the patients’ modified Rankin scale (mRS) at 90 days after strokeResults An incomplete ipsilateral COW was not predictive of the patients’ mRS at 90 days after stroke. Significant associations were shown for the patients’ baseline National Institutes of Health Stroke Scale (NIHSS), age and reperfusion status. The effect size suggests that a significant association of an incomplete COW with the mRS at 90 days may be obtained in cohorts of more than 3000 patients.Conclusions Compared with the established predictors NIHSS, age and reperfusion status, an incomplete COW is not associated with functional outcome after endovascular therapy. |
| first_indexed | 2024-12-12T09:38:03Z |
| format | Article |
| id | doaj.art-b99663712a0b4258b75ce3a8784f8a59 |
| institution | Directory Open Access Journal |
| issn | 2059-8696 |
| language | English |
| last_indexed | 2024-12-12T09:38:03Z |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Stroke and Vascular Neurology |
| spelling | doaj.art-b99663712a0b4258b75ce3a8784f8a592022-12-22T00:28:40ZengBMJ Publishing GroupStroke and Vascular Neurology2059-869610.1136/svn-2020-000491Circle of Willis variants are not associated with thrombectomy outcomesGregory W Albers0Christian Enzinger1Maarten Lansberg2Soren Christensen3Thomas Seifert-Held4Katharina Eberhard5Edith Hofer6Department of Neurology & Neurological Sciences, Stanford University, Stanford, California, USADepartment of Neurology, Medical University of Graz, Graz, Austria3 Department of Neurology, Stanford Stroke Center, Stanford University, Stanford, California, USA Department of Neurology, Stanford University, Stanford, California, USADepartment of Neurology, Medical University of Graz, Graz, AustriaCore Facility Computational Bioanalytics, Center for Medical Research, Medical University of Graz, Graz, AustriaDepartment of Neurology, Medical University of Graz, Graz, AustriaBackground The circle of Willis (COW) is part of the brain collateral system. The absence of COW segments may affect functional outcome in patients with ischaemic stroke undergoing endovascular therapy.Methods In 182 patients in the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution 2 Study and the CT Perfusion to Predict Response to Recanalisation in Ischaemic Stroke Project, COW anatomy was evaluated on postinterventional magnetic resonance angiography. The absence of the posterior communicating artery or the first segments of posterior or anterior cerebral arteries ipsilateral to the ischaemic infarction was rated as an incomplete COW. Logistic regression was applied to evaluate an association with the patients’ modified Rankin scale (mRS) at 90 days after strokeResults An incomplete ipsilateral COW was not predictive of the patients’ mRS at 90 days after stroke. Significant associations were shown for the patients’ baseline National Institutes of Health Stroke Scale (NIHSS), age and reperfusion status. The effect size suggests that a significant association of an incomplete COW with the mRS at 90 days may be obtained in cohorts of more than 3000 patients.Conclusions Compared with the established predictors NIHSS, age and reperfusion status, an incomplete COW is not associated with functional outcome after endovascular therapy.https://svn.bmj.com/content/early/2020/10/11/svn-2020-000491.full |
| spellingShingle | Gregory W Albers Christian Enzinger Maarten Lansberg Soren Christensen Thomas Seifert-Held Katharina Eberhard Edith Hofer Circle of Willis variants are not associated with thrombectomy outcomes Stroke and Vascular Neurology |
| title | Circle of Willis variants are not associated with thrombectomy outcomes |
| title_full | Circle of Willis variants are not associated with thrombectomy outcomes |
| title_fullStr | Circle of Willis variants are not associated with thrombectomy outcomes |
| title_full_unstemmed | Circle of Willis variants are not associated with thrombectomy outcomes |
| title_short | Circle of Willis variants are not associated with thrombectomy outcomes |
| title_sort | circle of willis variants are not associated with thrombectomy outcomes |
| url | https://svn.bmj.com/content/early/2020/10/11/svn-2020-000491.full |
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